| SP | deGrom, J.deGrom, Jacob † $$ >> | 33 | 2021 | R | 100 | 27 | 27 | 15 | 4 | 2.73 | .280 | 1.16 | 7.7 | 2.7 | 9.5 | 181.1 | 155 | 58 | 55 | 12 | 55 | 191 | 1 | 0 | 0 | 0 | 19 | 2 | 0 | 2.70 |
| SP | Richard, J.Richard, J.R. $ >> | 30 | 1980 | R | 90 | 27 | 27 | 13 | 7 | 2.71 | .261 | 1.05 | 6.3 | 3.2 | 7.4 | 182.1 | 128 | 59 | 55 | 11 | 64 | 150 | 0 | 0 | 0 | 0 | 19 | 1 | 1 | 3.21 |
| SP | Leonard, D.Leonard, Dutch >> | 22 | 1914 | L | 91 | 26 | 26 | 15 | 4 | 2.50 | .282 | 1.16 | 7.4 | 3.0 | 5.4 | 176.1 | 145 | 55 | 49 | 8 | 59 | 106 | 1 | 0 | 0 | 0 | 18 | 4 | 3 | 3.46 |
| SP | Hearn, J.Hearn, Jim $$ >> | 29 | 1950 | R | 75 | 25 | 25 | 15 | 5 | 3.43 | .302 | 1.28 | 7.7 | 3.8 | 3.1 | 170.2 | 146 | 71 | 65 | 20 | 72 | 58 | 0 | 0 | 0 | 0 | 18 | 3 | 3 | 5.17 |
| RP | Hader, J.Hader, Josh † >> | 24 | 2018 | L | 93 | 73 | 0 | 5 | 5 | 3.91 | .319 | 1.40 | 7.0 | 5.6 | 11.0 | 106.0 | 82 | 47 | 46 | 9 | 66 | 129 | 0 | 10 | 8 | 0 | 0 | 1 | 0 | 3.57 |
| RP | Holland, G.Holland, Greg >> | 27 | 2013 | R | 71 | 59 | 0 | 7 | 3 | 2.69 | .292 | 1.24 | 6.9 | 4.3 | 7.3 | 73.2 | 56 | 23 | 22 | 3 | 35 | 59 | 0 | 7 | 2 | 0 | 0 | 0 | 3 | 3.36 |
| RP | Percival, T.Percival, Troy >> | 26 | 1995 | R | 82 | 44 | 0 | 3 | 2 | 3.47 | .296 | 1.24 | 6.8 | 4.5 | 7.4 | 46.2 | 35 | 19 | 18 | 3 | 23 | 38 | 0 | 11 | 3 | 0 | 0 | 1 | 2 | 3.76 |
| RP | Devine, J.Devine, Joey >> | 25 | 2008 | R | 80 | 27 | 0 | 3 | 2 | 1.61 | .236 | 0.93 | 6.4 | 1.9 | 6.8 | 28.0 | 20 | 6 | 5 | 2 | 6 | 21 | 0 | 6 | 0 | 0 | 0 | 0 | 0 | 3.07 |
| RP | Urbina, U.Urbina, Ugueth >> | 24 | 1998 | R | 58 | 18 | 0 | 1 | 1 | 5.29 | .363 | 1.71 | 11.1 | 4.2 | 10.6 | 17.0 | 21 | 10 | 10 | 0 | 8 | 20 | 0 | 2 | 0 | 0 | 0 | 0 | 1 | 2.06 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 63 | 24 | 0 | 0 | 0 | 3.34 | .341 | 1.52 | 6.8 | 7.1 | 9.3 | 29.2 | 22 | 11 | 11 | 3 | 23 | 30 | 0 | 2 | 0 | 0 | 0 | 1 | 1 | 4.76 |
| SP | Reulbach, E.Reulbach, Ed >> | 24 | 1906 | R | 61 | 2 | 0 | 0 | 0 | 0.00 | .182 | 0.67 | 6.0 | 0.0 | 3.0 | 3.0 | 2 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.33 |