| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 92 | 29 | 29 | 13 | 7 | 4.33 | .312 | 1.35 | 8.7 | 3.5 | 6.6 | 180.2 | 174 | 92 | 87 | 20 | 69 | 132 | 2 | 0 | 0 | 0 | 15 | 3 | 3 | 4.18 |
| SP | Leonard, D.Leonard, Dutch >> | 22 | 1914 | L | 91 | 28 | 28 | 10 | 6 | 3.54 | .274 | 1.13 | 6.9 | 3.2 | 5.3 | 173.0 | 133 | 71 | 68 | 18 | 62 | 101 | 1 | 0 | 0 | 0 | 17 | 1 | 4 | 4.28 |
| SP | Fernandez, S.Fernandez, Sid # >> | 23 | 1985 | L | 49 | 29 | 27 | 10 | 9 | 3.72 | .285 | 1.17 | 7.1 | 3.5 | 7.2 | 169.1 | 133 | 70 | 70 | 17 | 65 | 135 | 2 | 0 | 0 | 0 | 19 | 4 | 5 | 3.93 |
| RP | Clippard, T.Clippard, Tyler † >> | 26 | 2011 | R | 79 | 86 | 0 | 6 | 1 | 3.22 | .302 | 1.28 | 7.8 | 3.7 | 8.1 | 89.1 | 77 | 37 | 32 | 8 | 37 | 80 | 0 | 5 | 1 | 0 | 0 | 2 | 0 | 3.69 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 78 | 85 | 0 | 3 | 5 | 4.41 | .329 | 1.45 | 8.9 | 4.3 | 7.9 | 65.1 | 64 | 33 | 32 | 11 | 31 | 57 | 0 | 5 | 5 | 0 | 0 | 1 | 6 | 4.92 |
| RP | Gregerson, L.Gregerson, Luke >> | 26 | 2010 | R | 73 | 73 | 0 | 4 | 2 | 3.91 | .332 | 1.45 | 9.1 | 3.9 | 7.8 | 69.0 | 70 | 33 | 30 | 10 | 30 | 60 | 0 | 9 | 3 | 0 | 0 | 3 | 0 | 4.58 |
| RP | Zimmerman, J.Zimmerman, Jeff >> | 27 | 1999 | R | 70 | 46 | 0 | 2 | 4 | 4.02 | .341 | 1.53 | 9.0 | 4.8 | 5.4 | 47.0 | 47 | 22 | 21 | 4 | 25 | 28 | 0 | 5 | 5 | 0 | 0 | 1 | 1 | 4.57 |
| RP | Wilhelm, H.Wilhelm, Hoyt >> | 43 | 1965 | R | 69 | 38 | 0 | 3 | 7 | 4.22 | .292 | 1.17 | 7.8 | 2.9 | 4.6 | 59.2 | 51 | 29 | 28 | 6 | 19 | 30 | 0 | 5 | 4 | 0 | 0 | 4 | 4 | 4.47 |
| RP | Messersmith, A.Messersmith, Andy >> | 23 | 1968 | R | 58 | 11 | 0 | 0 | 0 | 0.00 | .317 | 1.32 | 7.6 | 4.8 | 6.9 | 13.2 | 11 | 0 | 0 | 0 | 7 | 10 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 3.31 |