| SP | Martinez, P.Martinez, Pedro >> | 29 | 2000 | R | 100 | 27 | 27 | 9 | 11 | 4.42 | .307 | 1.31 | 8.6 | 3.2 | 8.3 | 175.0 | 167 | 92 | 86 | 26 | 63 | 161 | 4 | 0 | 0 | 1 | 14 | 3 | 3 | 4.22 |
| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 84 | 26 | 26 | 8 | 16 | 5.47 | .324 | 1.41 | 10.0 | 2.8 | 8.3 | 164.2 | 182 | 105 | 100 | 27 | 51 | 152 | 3 | 0 | 0 | 0 | 11 | 4 | 0 | 4.29 |
| RP | Uehara, K.Uehara, Koji † >> | 38 | 2013 | R | 100 | 73 | 0 | 8 | 2 | 3.40 | .297 | 1.26 | 8.5 | 2.9 | 8.5 | 82.0 | 77 | 33 | 31 | 7 | 26 | 77 | 0 | 3 | 0 | 0 | 0 | 1 | 1 | 3.22 |
| RP | Feliz, N.Feliz, Neftali >> | 21 | 2009 | R | 97 | 65 | 0 | 3 | 1 | 3.89 | .324 | 1.41 | 9.0 | 3.8 | 8.5 | 71.2 | 71 | 34 | 31 | 10 | 30 | 67 | 0 | 6 | 2 | 0 | 0 | 2 | 0 | 4.30 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 55 | 0 | 4 | 1 | 4.20 | .289 | 1.20 | 7.3 | 3.6 | 10.3 | 70.2 | 57 | 33 | 33 | 10 | 28 | 80 | 0 | 4 | 0 | 0 | 0 | 1 | 0 | 3.81 |
| RP | Pagan, E.Pagan, Emilio >> | 28 | 2019 | R | 77 | 46 | 0 | 2 | 1 | 4.36 | .306 | 1.32 | 10.0 | 2.0 | 9.2 | 53.2 | 59 | 28 | 26 | 9 | 12 | 54 | 0 | 6 | 0 | 0 | 0 | 0 | 3 | 3.85 |