| SP | Koufax, S.Koufax, Sandy $ >> | 30 | 1965 | L | 97 | 29 | 29 | 12 | 15 | 3.58 | .277 | 1.13 | 7.6 | 2.6 | 7.7 | 231.0 | 195 | 105 | 92 | 26 | 67 | 198 | 16 | 0 | 0 | 2 | 16 | 3 | 9 | 3.66 |
| SP | Maddux, G.Maddux, Greg $$ >> | 29 | 1995 | R | 89 | 29 | 29 | 17 | 11 | 3.60 | .273 | 1.11 | 8.1 | 1.9 | 5.5 | 217.1 | 196 | 94 | 87 | 15 | 46 | 132 | 6 | 0 | 0 | 2 | 19 | 3 | 5 | 3.36 |
| SP | Santana, J.Santana, Johan # >> | 25 | 2004 | L | 86 | 28 | 28 | 11 | 10 | 4.68 | .286 | 1.18 | 8.1 | 2.4 | 7.2 | 148.0 | 134 | 84 | 77 | 20 | 40 | 119 | 0 | 0 | 0 | 0 | 6 | 4 | 2 | 4.04 |
| SP | Brown, M.Brown, Mordecai >> | 32 | 1908 | R | 85 | 28 | 28 | 13 | 8 | 2.87 | .265 | 1.07 | 7.4 | 2.2 | 4.2 | 197.1 | 162 | 69 | 63 | 13 | 49 | 92 | 3 | 0 | 0 | 1 | 19 | 2 | 2 | 3.70 |
| SP | Hunter, C.Hunter, Catfish # >> | 26 | 1972 | R | 81 | 27 | 27 | 11 | 12 | 3.72 | .293 | 1.23 | 8.1 | 3.0 | 3.7 | 176.2 | 159 | 74 | 73 | 14 | 58 | 72 | 2 | 0 | 0 | 1 | 17 | 3 | 3 | 4.26 |
| RP | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 87 | 73 | 0 | 6 | 2 | 3.83 | .300 | 1.26 | 9.5 | 1.9 | 6.4 | 87.0 | 92 | 43 | 37 | 11 | 18 | 62 | 0 | 5 | 2 | 0 | 0 | 2 | 0 | 3.91 |
| RP | Chapman, A.Chapman, Aroldis >> | 26 | 2014 | L | 94 | 76 | 0 | 1 | 0 | 3.30 | .244 | 0.97 | 4.7 | 4.1 | 12.0 | 60.0 | 31 | 23 | 22 | 6 | 27 | 80 | 0 | 0 | 1 | 0 | 0 | 0 | 4 | 2.98 |
| RP | Gallegos, G.Gallegos, Giovanny >> | 27 | 2019 | R | 82 | 58 | 0 | 0 | 4 | 4.01 | .330 | 1.44 | 8.5 | 4.5 | 7.4 | 58.1 | 55 | 32 | 26 | 8 | 29 | 48 | 0 | 10 | 3 | 0 | 0 | 2 | 3 | 4.74 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 76 | 37 | 0 | 1 | 1 | 3.05 | .239 | 0.94 | 6.4 | 2.2 | 7.5 | 41.1 | 29 | 17 | 14 | 8 | 10 | 34 | 0 | 8 | 1 | 0 | 0 | 0 | 0 | 4.61 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 75 | 17 | 0 | 1 | 3 | 3.38 | .324 | 1.38 | 7.3 | 5.1 | 11.3 | 16.0 | 13 | 6 | 6 | 0 | 9 | 20 | 0 | 3 | 0 | 0 | 0 | 1 | 1 | 2.38 |
| RP | Broxton, J.Broxton, Jonathan >> | 25 | 2009 | R | 63 | 25 | 0 | 0 | 0 | 1.21 | .205 | 0.78 | 5.9 | 1.2 | 8.7 | 29.2 | 19 | 6 | 4 | 3 | 4 | 28 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.83 |