| SP | Koufax, S.Koufax, Sandy † $$ >> | 30 | 1965 | L | 98 | 27 | 27 | 15 | 9 | 2.26 | .233 | 0.89 | 6.0 | 2.0 | 8.3 | 231.0 | 154 | 58 | 58 | 13 | 51 | 212 | 19 | 0 | 0 | 5 | 23 | 5 | 3 | 2.62 |
| SP | Maddux, G.Maddux, Greg † $ >> | 29 | 1995 | R | 89 | 26 | 26 | 13 | 7 | 3.45 | .273 | 1.12 | 8.4 | 1.7 | 4.7 | 198.0 | 184 | 79 | 76 | 13 | 37 | 104 | 3 | 0 | 0 | 1 | 19 | 2 | 2 | 3.39 |
| SP | Alexander, P.Alexander, Pete >> | 28 | 1915 | R | 88 | 26 | 26 | 13 | 6 | 3.22 | .266 | 1.07 | 7.3 | 2.4 | 4.8 | 176.0 | 143 | 72 | 63 | 19 | 46 | 94 | 2 | 0 | 0 | 2 | 18 | 2 | 5 | 4.15 |
| SP | Santana, J.Santana, Johan # >> | 25 | 2004 | L | 86 | 26 | 26 | 8 | 6 | 3.15 | .253 | 1.00 | 6.3 | 2.7 | 7.6 | 145.2 | 102 | 54 | 51 | 11 | 44 | 123 | 1 | 0 | 0 | 1 | 10 | 2 | 4 | 3.24 |
| SP | Hunter, C.Hunter, Catfish >> | 26 | 1972 | R | 81 | 26 | 26 | 14 | 3 | 3.29 | .288 | 1.20 | 7.3 | 3.5 | 4.4 | 169.2 | 138 | 71 | 62 | 15 | 65 | 82 | 0 | 0 | 0 | 0 | 17 | 3 | 3 | 4.39 |
| RP | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 87 | 61 | 0 | 5 | 4 | 2.26 | .279 | 1.14 | 8.1 | 2.2 | 7.4 | 83.2 | 75 | 24 | 21 | 1 | 20 | 68 | 0 | 8 | 3 | 0 | 0 | 2 | 0 | 2.31 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 55 | 0 | 2 | 4 | 3.86 | .305 | 1.29 | 8.6 | 3.0 | 7.2 | 70.0 | 67 | 30 | 30 | 3 | 23 | 56 | 0 | 9 | 3 | 0 | 0 | 2 | 1 | 3.03 |
| RP | Clippard, T.Clippard, Tyler >> | 26 | 2011 | R | 79 | 43 | 0 | 4 | 3 | 3.42 | .299 | 1.26 | 6.1 | 5.2 | 8.6 | 50.0 | 34 | 20 | 19 | 3 | 29 | 48 | 0 | 9 | 2 | 0 | 0 | 1 | 0 | 3.66 |
| RP | Boxberger, B.Boxberger, Brad >> | 26 | 2014 | R | 83 | 31 | 0 | 3 | 2 | 3.44 | .282 | 1.18 | 6.4 | 4.2 | 8.2 | 34.0 | 24 | 15 | 13 | 1 | 16 | 31 | 0 | 0 | 4 | 0 | 0 | 0 | 2 | 2.97 |
| RP | Hochevar, L.Hochevar, Luke >> | 30 | 2013 | R | 77 | 23 | 0 | 1 | 5 | 6.16 | .345 | 1.53 | 11.8 | 1.9 | 6.6 | 19.0 | 25 | 14 | 13 | 2 | 4 | 14 | 0 | 3 | 0 | 0 | 0 | 1 | 0 | 3.68 |
| SP | Drysdale, D.Drysdale, Don >> | 28 | 1964 | R | 59 | 5 | 0 | 2 | 0 | 0.00 | .083 | 0.27 | 3.0 | 0.0 | 3.0 | 3.2 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.33 |