| SP | Scherzer, M.Scherzer, Max >> | 33 | 2017 | R | 95 | 10 | 10 | 5 | 5 | 3.09 | .302 | 1.22 | 7.3 | 3.8 | 9.0 | 67.0 | 54 | 25 | 23 | 7 | 28 | 67 | 0 | 0 | 0 | 0 | 6 | 5 | 2 | 3.84 |
| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 93 | 10 | 10 | 4 | 1 | 2.36 | .252 | 1.01 | 6.3 | 2.8 | 6.9 | 76.1 | 53 | 21 | 20 | 4 | 24 | 58 | 2 | 0 | 0 | 1 | 9 | 0 | 1 | 3.11 |
| SP | Hernandez, F.Hernandez, Felix >> | 28 | 2014 | R | 79 | 9 | 9 | 2 | 3 | 3.58 | .272 | 1.10 | 6.9 | 3.1 | 9.2 | 55.1 | 42 | 22 | 22 | 7 | 19 | 56 | 0 | 0 | 0 | 0 | 5 | 1 | 1 | 3.71 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 30 | 0 | 1 | 1 | 2.17 | .277 | 1.13 | 7.8 | 2.4 | 9.2 | 37.1 | 32 | 11 | 9 | 3 | 10 | 38 | 0 | 3 | 2 | 0 | 0 | 1 | 1 | 2.89 |
| RP | Boxberger, B.Boxberger, Brad >> | 26 | 2014 | R | 83 | 21 | 0 | 4 | 1 | 2.93 | .320 | 1.41 | 6.3 | 6.7 | 9.3 | 27.2 | 19 | 10 | 9 | 2 | 20 | 28 | 0 | 2 | 1 | 0 | 0 | 0 | 2 | 4.11 |
| RP | Pagan, E.Pagan, Emilio >> | 28 | 2019 | R | 77 | 16 | 0 | 0 | 3 | 4.95 | .294 | 1.25 | 8.1 | 3.2 | 8.1 | 20.0 | 18 | 11 | 11 | 2 | 7 | 18 | 0 | 2 | 1 | 0 | 0 | 0 | 1 | 3.55 |