| SP | Clemens, R.Clemens, Roger >> | 43 | 2005 | R | 94 | 34 | 34 | 10 | 12 | 4.02 | .319 | 1.37 | 8.4 | 3.9 | 6.6 | 206.0 | 193 | 93 | 92 | 18 | 90 | 151 | 1 | 0 | 0 | 0 | 19 | 7 | 2 | 4.08 |
| SP | Zambrano, C.Zambrano, Carlos # >> | 24 | 2005 | R | 70 | 33 | 33 | 10 | 13 | 4.46 | .316 | 1.33 | 7.8 | 4.2 | 6.3 | 193.2 | 167 | 100 | 96 | 36 | 91 | 136 | 0 | 0 | 0 | 0 | 16 | 10 | 6 | 5.59 |
| SP | Clement, M.Clement, Matt >> | 28 | 2002 | R | 53 | 32 | 32 | 9 | 11 | 4.96 | .337 | 1.48 | 8.7 | 4.6 | 8.6 | 194.0 | 188 | 109 | 107 | 29 | 100 | 185 | 0 | 0 | 0 | 0 | 17 | 8 | 5 | 4.71 |
| SP | Willis, D.Willis, Dontrelle >> | 23 | 2005 | L | 47 | 32 | 32 | 12 | 7 | 4.95 | .328 | 1.44 | 9.8 | 3.2 | 6.4 | 192.2 | 209 | 110 | 106 | 30 | 69 | 136 | 0 | 0 | 0 | 0 | 15 | 4 | 3 | 4.76 |
| SP | Beckett, J.Beckett, Josh # >> | 27 | 2007 | R | 45 | 31 | 31 | 9 | 7 | 5.68 | .346 | 1.56 | 10.4 | 3.7 | 7.7 | 188.2 | 217 | 123 | 119 | 31 | 78 | 161 | 1 | 0 | 0 | 1 | 10 | 4 | 2 | 4.74 |
| RP | Vizcaino, L.Vizcaino, Luis >> | 28 | 2002 | R | 47 | 87 | 0 | 3 | 9 | 5.57 | .314 | 1.36 | 8.5 | 3.9 | 6.6 | 72.2 | 68 | 47 | 45 | 10 | 31 | 53 | 0 | 5 | 6 | 0 | 0 | 1 | 3 | 4.67 |
| RP | Howell, J.Howell, J.P. >> | 25 | 2008 | L | 33 | 102 | 0 | 4 | 4 | 6.78 | .344 | 1.55 | 8.8 | 5.3 | 9.4 | 75.2 | 73 | 58 | 57 | 17 | 44 | 78 | 0 | 7 | 8 | 0 | 0 | 2 | 2 | 5.71 |
| RP | Farnsworth, K.Farnsworth, Kyle >> | 25 | 2001 | R | 22 | 75 | 0 | 6 | 4 | 4.95 | .335 | 1.44 | 9.5 | 3.6 | 9.8 | 72.2 | 76 | 41 | 40 | 14 | 29 | 78 | 0 | 7 | 1 | 0 | 0 | 5 | 1 | 4.78 |
| SP | Arroyo, B.Arroyo, Bronson >> | 29 | 2006 | R | 21 | 5 | 0 | 2 | 2 | 5.68 | .269 | 1.11 | 9.0 | 1.5 | 9.0 | 6.1 | 6 | 4 | 4 | 2 | 1 | 6 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5.83 |
| SP | Matsuzaka, D.Matsuzaka, Daisuke >> | 28 | 2008 | R | 33 | 46 | 0 | 9 | 7 | 3.31 | .333 | 1.47 | 7.3 | 6.0 | 7.8 | 70.2 | 57 | 31 | 26 | 5 | 47 | 61 | 0 | 7 | 4 | 0 | 0 | 2 | 4 | 4.29 |