| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 100 | 34 | 34 | 11 | 14 | 3.42 | .287 | 1.18 | 7.4 | 3.2 | 8.4 | 228.2 | 188 | 90 | 87 | 29 | 82 | 212 | 5 | 0 | 0 | 2 | 22 | 6 | 6 | 3.95 |
| SP | Perez, O.Perez, Odalis >> | 25 | 2002 | L | 81 | 32 | 32 | 14 | 11 | 3.48 | .284 | 1.13 | 7.9 | 2.3 | 6.9 | 199.1 | 175 | 86 | 77 | 30 | 50 | 153 | 2 | 0 | 0 | 2 | 21 | 12 | 2 | 4.36 |
| SP | Pettitte, A.Pettitte, Andy >> | 33 | 2005 | L | 77 | 32 | 32 | 7 | 7 | 4.90 | .305 | 1.27 | 9.2 | 2.3 | 6.7 | 180.0 | 183 | 105 | 98 | 28 | 46 | 133 | 0 | 0 | 0 | 0 | 15 | 8 | 4 | 4.44 |
| SP | Sabathia, C.Sabathia, CC >> | 28 | 2008 | L | 60 | 31 | 31 | 9 | 15 | 5.59 | .328 | 1.42 | 9.3 | 3.5 | 6.6 | 178.2 | 184 | 125 | 111 | 36 | 70 | 130 | 7 | 0 | 0 | 1 | 11 | 8 | 2 | 5.48 |
| RP | Wagner, B.Wagner, Billy >> | 32 | 2003 | L | 89 | 61 | 0 | 5 | 2 | 1.78 | .231 | 0.89 | 5.0 | 3.0 | 9.4 | 81.0 | 45 | 21 | 16 | 5 | 27 | 85 | 0 | 8 | 2 | 0 | 0 | 1 | 4 | 2.74 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 79 | 49 | 0 | 6 | 4 | 2.97 | .303 | 1.30 | 6.0 | 5.9 | 8.1 | 63.2 | 42 | 23 | 21 | 9 | 41 | 57 | 0 | 5 | 2 | 0 | 0 | 0 | 2 | 5.00 |
| RP | Gonzalez, M.Gonzalez, Mike >> | 26 | 2004 | L | 74 | 34 | 0 | 4 | 3 | 3.05 | .272 | 1.10 | 7.6 | 2.4 | 11.1 | 38.1 | 32 | 13 | 13 | 4 | 10 | 47 | 0 | 6 | 2 | 0 | 0 | 1 | 3 | 2.76 |
| RP | Wuertz, M.Wuertz, Michael >> | 31 | 2009 | R | 71 | 18 | 0 | 0 | 3 | 3.00 | .338 | 1.47 | 9.0 | 4.2 | 9.6 | 15.0 | 15 | 5 | 5 | 2 | 7 | 16 | 0 | 2 | 0 | 0 | 0 | 1 | 2 | 4.20 |
| RP | Street, H.Street, Huston >> | 24 | 2007 | R | 68 | 9 | 0 | 1 | 1 | 5.06 | .347 | 1.41 | 9.0 | 4.5 | 8.1 | 10.2 | 10 | 7 | 6 | 2 | 5 | 9 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 5.90 |
| RP | Williamson, S.Williamson, Scott >> | 26 | 2002 | R | 51 | 14 | 0 | 0 | 0 | 5.65 | .358 | 1.67 | 12.2 | 3.2 | 8.4 | 14.1 | 19 | 12 | 9 | 3 | 5 | 13 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5.00 |
| SP | Garcia, F.Garcia, Freddy >> | 26 | 2001 | R | 59 | 25 | 0 | 8 | 4 | 3.49 | .299 | 1.27 | 8.4 | 3.1 | 7.1 | 126.1 | 117 | 49 | 49 | 14 | 43 | 100 | 0 | 0 | 0 | 0 | 0 | 2 | 2 | 3.93 |