| SP | Johnson, R.Johnson, Randy # >> | 38 | 2001 | L | 97 | 12 | 12 | 6 | 3 | 3.86 | .260 | 1.01 | 6.9 | 2.2 | 10.9 | 77.0 | 59 | 33 | 33 | 9 | 19 | 93 | 2 | 0 | 0 | 2 | 6 | 3 | 2 | 2.96 |
| SP | Halladay, R.Halladay, Roy >> | 28 | 2005 | R | 87 | 12 | 12 | 6 | 3 | 3.29 | .242 | 0.96 | 7.4 | 1.2 | 5.3 | 87.2 | 72 | 33 | 32 | 15 | 12 | 51 | 4 | 0 | 0 | 1 | 8 | 0 | 1 | 4.48 |
| SP | Williams, W.Williams, Woody >> | 36 | 2002 | R | 79 | 12 | 12 | 4 | 5 | 6.24 | .344 | 1.54 | 10.5 | 3.5 | 6.6 | 70.2 | 82 | 49 | 49 | 21 | 27 | 51 | 0 | 0 | 0 | 0 | 2 | 2 | 2 | 6.69 |
| SP | Buehrle, M.Buehrle, Mark >> | 22 | 2001 | L | 67 | 12 | 12 | 2 | 4 | 4.99 | .343 | 1.54 | 10.8 | 3.1 | 5.3 | 70.1 | 84 | 40 | 39 | 12 | 24 | 41 | 0 | 0 | 0 | 0 | 4 | 2 | 0 | 5.17 |
| SP | Harang, A.Harang, Aaron >> | 29 | 2007 | R | 51 | 12 | 12 | 6 | 5 | 5.37 | .324 | 1.39 | 10.4 | 2.2 | 6.8 | 65.1 | 75 | 39 | 39 | 9 | 16 | 49 | 0 | 0 | 0 | 0 | 5 | 3 | 1 | 4.17 |
| CL | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 96 | 23 | 0 | 0 | 4 | 3.74 | .286 | 1.15 | 7.3 | 3.4 | 9.4 | 21.2 | 17 | 9 | 9 | 3 | 8 | 22 | 0 | 11 | 3 | 0 | 0 | 1 | 0 | 4.05 |
| RP | Foulke, K.Foulke, Keith >> | 31 | 2003 | R | 78 | 32 | 0 | 0 | 1 | 1.97 | .207 | 0.75 | 4.8 | 2.0 | 7.0 | 32.0 | 17 | 7 | 7 | 6 | 7 | 25 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 4.63 |
| RP | Perez, R.Perez, Rafael >> | 25 | 2007 | L | 65 | 34 | 0 | 1 | 1 | 2.93 | .246 | 0.98 | 7.8 | 1.2 | 9.9 | 30.2 | 26 | 10 | 10 | 4 | 4 | 33 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 2.93 |
| RP | Sasaki, K.Sasaki, Kazuhiro >> | 33 | 2001 | R | 64 | 18 | 0 | 1 | 0 | 4.41 | .329 | 1.41 | 10.7 | 2.3 | 7.9 | 16.1 | 19 | 9 | 8 | 2 | 4 | 14 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 3.81 |
| SP | Arroyo, B.Arroyo, Bronson >> | 29 | 2006 | R | 21 | 9 | 0 | 2 | 1 | 4.67 | .308 | 1.22 | 8.7 | 2.3 | 6.0 | 27.0 | 26 | 15 | 14 | 5 | 7 | 18 | 0 | 0 | 0 | 0 | 0 | 3 | 0 | 5.19 |