| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 95 | 12 | 12 | 7 | 0 | 2.84 | .265 | 1.07 | 6.2 | 3.5 | 8.7 | 79.1 | 54 | 26 | 25 | 8 | 31 | 76 | 0 | 0 | 0 | 0 | 9 | 1 | 0 | 3.61 |
| SP | Duchscherer, J.Duchscherer, Justin >> | 31 | 2008 | R | 84 | 12 | 12 | 5 | 5 | 5.27 | .317 | 1.33 | 8.9 | 3.2 | 6.6 | 71.2 | 70 | 44 | 42 | 12 | 25 | 52 | 1 | 0 | 0 | 0 | 4 | 5 | 2 | 5.00 |
| SP | Pettitte, A.Pettitte, Andy >> | 33 | 2005 | L | 78 | 12 | 12 | 5 | 4 | 4.58 | .312 | 1.32 | 9.8 | 2.3 | 7.6 | 72.2 | 78 | 38 | 37 | 15 | 18 | 61 | 1 | 0 | 0 | 1 | 5 | 3 | 0 | 4.89 |
| SP | Mussina, M.Mussina, Mike >> | 33 | 2001 | R | 68 | 12 | 12 | 6 | 0 | 4.46 | .299 | 1.27 | 9.1 | 2.4 | 7.6 | 76.2 | 77 | 39 | 38 | 9 | 20 | 64 | 0 | 0 | 0 | 0 | 9 | 1 | 2 | 3.68 |
| SP | Maddux, G.Maddux, Greg >> | 34 | 2000 | R | 58 | 12 | 12 | 7 | 2 | 3.30 | .323 | 1.41 | 9.8 | 2.9 | 5.4 | 87.1 | 95 | 32 | 32 | 8 | 28 | 52 | 2 | 0 | 0 | 1 | 8 | 2 | 1 | 4.03 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 100 | 35 | 0 | 1 | 1 | 2.90 | .359 | 1.65 | 9.3 | 5.5 | 8.1 | 31.0 | 32 | 14 | 10 | 3 | 19 | 28 | 0 | 3 | 2 | 0 | 0 | 1 | 0 | 4.39 |
| RP | Dotel, O.Dotel, Octavio >> | 29 | 2002 | R | 89 | 30 | 0 | 0 | 1 | 4.88 | .347 | 1.56 | 10.5 | 3.8 | 11.3 | 31.1 | 36 | 17 | 17 | 5 | 13 | 39 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 3.94 |
| RP | Rhodes, A.Rhodes, Arthur >> | 33 | 2002 | L | 86 | 30 | 0 | 2 | 0 | 7.15 | .340 | 1.41 | 7.8 | 5.3 | 7.8 | 22.2 | 19 | 18 | 18 | 4 | 13 | 19 | 0 | 2 | 1 | 0 | 0 | 3 | 0 | 5.82 |
| RP | Rodriguez, F.Rodriguez, Francisco >> | 22 | 2004 | R | 70 | 21 | 0 | 2 | 3 | 2.81 | .260 | 1.05 | 5.4 | 4.3 | 12.2 | 25.2 | 15 | 8 | 8 | 4 | 12 | 34 | 0 | 1 | 3 | 0 | 0 | 0 | 0 | 3.80 |
| RP | Wheeler, D.Wheeler, Dan >> | 32 | 2009 | R | 67 | 18 | 0 | 2 | 2 | 3.27 | .224 | 0.86 | 7.0 | 0.8 | 9.4 | 22.0 | 17 | 8 | 8 | 4 | 2 | 23 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 3.55 |
| RP | Thornton, M.Thornton, Matt >> | 32 | 2008 | L | 54 | 37 | 0 | 2 | 3 | 2.57 | .295 | 1.14 | 7.2 | 3.1 | 9.3 | 35.0 | 28 | 11 | 10 | 1 | 12 | 36 | 0 | 2 | 3 | 0 | 0 | 4 | 2 | 2.69 |