| SP | Scherzer, M.Scherzer, Max † >> | 33 | 2017 | R | 98 | 34 | 34 | 14 | 8 | 3.09 | .297 | 1.23 | 7.3 | 3.7 | 10.2 | 233.0 | 190 | 88 | 80 | 20 | 97 | 265 | 2 | 0 | 0 | 0 | 23 | 8 | 3 | 3.19 |
| SP | Hudson, D.Hudson, Daniel >> | 23 | 2010 | R | 82 | 33 | 33 | 16 | 14 | 4.71 | .328 | 1.43 | 9.5 | 3.4 | 7.4 | 219.2 | 232 | 123 | 115 | 31 | 83 | 180 | 1 | 0 | 0 | 1 | 17 | 7 | 9 | 4.43 |
| SP | Richards, G.Richards, Garrett # >> | 26 | 2014 | R | 73 | 32 | 32 | 13 | 8 | 4.55 | .334 | 1.48 | 9.7 | 3.7 | 8.7 | 199.2 | 214 | 113 | 101 | 28 | 82 | 193 | 0 | 0 | 0 | 0 | 15 | 5 | 19 | 4.20 |
| SP | Shields, J.Shields, James >> | 30 | 2011 | R | 63 | 32 | 32 | 14 | 12 | 5.83 | .352 | 1.61 | 10.4 | 4.1 | 7.5 | 208.1 | 241 | 146 | 135 | 23 | 94 | 173 | 3 | 0 | 0 | 2 | 14 | 4 | 2 | 4.19 |
| SP | Wainwright, A.Wainwright, Adam >> | 29 | 2010 | R | 57 | 31 | 30 | 12 | 15 | 5.41 | .344 | 1.53 | 10.1 | 3.8 | 7.9 | 201.1 | 225 | 128 | 121 | 31 | 84 | 177 | 4 | 0 | 0 | 0 | 11 | 8 | 3 | 4.62 |
| CL | Jansen, K.Jansen, Kenley † >> | 28 | 2016 | R | 98 | 64 | 0 | 3 | 3 | 3.15 | .275 | 1.12 | 7.8 | 2.4 | 11.4 | 68.2 | 59 | 25 | 24 | 3 | 18 | 86 | 0 | 32 | 4 | 0 | 0 | 1 | 1 | 1.88 |
| RP | Clippard, T.Clippard, Tyler >> | 26 | 2011 | R | 81 | 86 | 0 | 2 | 3 | 2.82 | .278 | 1.13 | 6.7 | 3.5 | 9.8 | 108.1 | 80 | 39 | 34 | 6 | 42 | 118 | 0 | 3 | 1 | 0 | 0 | 3 | 1 | 2.79 |
| RP | Gregerson, L.Gregerson, Luke >> | 26 | 2010 | R | 74 | 63 | 0 | 3 | 6 | 5.29 | .342 | 1.51 | 9.0 | 4.6 | 10.6 | 68.0 | 68 | 45 | 40 | 11 | 35 | 80 | 0 | 2 | 2 | 0 | 0 | 3 | 0 | 4.43 |
| RP | Thornburg, T.Thornburg, Tyler >> | 27 | 2016 | R | 67 | 58 | 0 | 4 | 5 | 3.05 | .287 | 1.18 | 6.7 | 3.9 | 9.3 | 62.0 | 46 | 22 | 21 | 8 | 27 | 64 | 0 | 0 | 1 | 0 | 0 | 2 | 3 | 4.02 |
| RP | Kelley, S.Kelley, Shawn >> | 32 | 2016 | R | 60 | 49 | 0 | 0 | 0 | 3.79 | .278 | 1.12 | 7.7 | 2.4 | 9.2 | 57.0 | 49 | 28 | 24 | 8 | 15 | 58 | 0 | 1 | 1 | 0 | 0 | 2 | 1 | 3.68 |
| SP | Castillo, L.Castillo, Luis >> | 26 | 2019 | R | 50 | 12 | 1 | 2 | 5 | 5.87 | .373 | 1.74 | 8.6 | 7.0 | 7.8 | 23.0 | 22 | 17 | 15 | 5 | 18 | 20 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 6.57 |