| SP | Verlander, J.Verlander, Justin >> | 36 | 2019 | R | 99 | 25 | 25 | 6 | 11 | 4.69 | .301 | 1.29 | 8.8 | 2.9 | 8.1 | 167.0 | 163 | 91 | 87 | 18 | 53 | 150 | 1 | 0 | 0 | 0 | 15 | 0 | 3 | 3.56 |
| SP | Nelson, R.Nelson, Roger # >> | 28 | 1972 | R | 84 | 24 | 24 | 6 | 9 | 7.30 | .370 | 1.71 | 11.5 | 4.0 | 4.8 | 119.2 | 152 | 99 | 97 | 22 | 53 | 64 | 0 | 0 | 0 | 0 | 5 | 6 | 1 | 5.82 |
| SP | Krause, H.Krause, Harry # >> | 21 | 1909 | L | 71 | 24 | 24 | 8 | 5 | 4.07 | .282 | 1.15 | 8.3 | 2.1 | 5.2 | 159.1 | 146 | 79 | 72 | 16 | 37 | 91 | 0 | 0 | 0 | 0 | 14 | 5 | 6 | 3.96 |
| RP | Uehara, K.Uehara, Koji † >> | 38 | 2013 | R | 100 | 62 | 0 | 5 | 1 | 2.71 | .273 | 1.12 | 7.5 | 2.6 | 9.0 | 89.2 | 74 | 27 | 27 | 10 | 26 | 89 | 0 | 6 | 2 | 0 | 0 | 1 | 0 | 3.37 |
| RP | Eckersley, D.Eckersley, Dennis >> | 36 | 1990 | R | 88 | 61 | 0 | 8 | 6 | 3.59 | .249 | 0.98 | 7.3 | 1.6 | 7.2 | 85.1 | 69 | 34 | 34 | 11 | 15 | 68 | 0 | 2 | 3 | 0 | 0 | 1 | 0 | 3.65 |
| RP | Williams, D.Williams, Devin >> | 28 | 2023 | R | 72 | 53 | 0 | 2 | 3 | 2.47 | .278 | 1.13 | 5.0 | 5.3 | 9.3 | 65.2 | 36 | 18 | 18 | 3 | 38 | 67 | 0 | 6 | 1 | 0 | 0 | 2 | 2 | 3.38 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 62 | 39 | 0 | 2 | 4 | 3.70 | .307 | 1.31 | 5.7 | 6.1 | 9.7 | 41.1 | 26 | 18 | 17 | 2 | 28 | 44 | 0 | 3 | 1 | 0 | 0 | 1 | 4 | 3.61 |
| RP | Messersmith, A.Messersmith, Andy >> | 23 | 1968 | R | 57 | 36 | 0 | 3 | 3 | 3.72 | .297 | 1.27 | 6.9 | 4.6 | 6.1 | 65.1 | 50 | 29 | 27 | 7 | 33 | 44 | 0 | 5 | 3 | 0 | 0 | 0 | 1 | 4.57 |
| SP | Hendricks, K.Hendricks, Kyle >> | 26 | 2016 | R | 56 | 11 | 0 | 2 | 2 | 3.09 | .375 | 1.80 | 10.6 | 6.5 | 7.4 | 11.2 | 13 | 5 | 4 | 1 | 8 | 9 | 0 | 1 | 3 | 0 | 0 | 0 | 0 | 4.73 |