| SP | deGrom, J.deGrom, Jacob $$ >> | 33 | 2021 | R | 100 | 21 | 21 | 5 | 7 | 4.79 | .303 | 1.27 | 8.5 | 2.9 | 9.3 | 118.1 | 112 | 64 | 63 | 18 | 38 | 122 | 0 | 0 | 0 | 0 | 10 | 4 | 0 | 3.98 |
| SP | Cueto, J.Cueto, Johnny >> | 28 | 2014 | R | 75 | 20 | 20 | 11 | 4 | 3.72 | .311 | 1.33 | 8.4 | 3.5 | 5.5 | 140.1 | 131 | 63 | 58 | 9 | 55 | 85 | 0 | 0 | 0 | 0 | 12 | 4 | 4 | 3.89 |
| SP | Reulbach, E.Reulbach, Ed >> | 24 | 1906 | R | 61 | 19 | 19 | 6 | 5 | 2.93 | .304 | 1.30 | 6.5 | 5.2 | 4.1 | 122.2 | 88 | 43 | 40 | 11 | 71 | 56 | 2 | 0 | 0 | 1 | 12 | 2 | 4 | 5.05 |
| SP | Cicotte, E.Cicotte, Eddie # >> | 33 | 1917 | R | 74 | 19 | 19 | 9 | 6 | 4.39 | .310 | 1.30 | 9.5 | 2.3 | 4.8 | 112.2 | 118 | 56 | 55 | 7 | 29 | 60 | 2 | 0 | 0 | 2 | 11 | 5 | 2 | 3.65 |
| CL | Doolittle, S.Doolittle, Sean † >> | 31 | 2018 | L | 99 | 40 | 0 | 3 | 7 | 2.91 | .228 | 0.84 | 4.9 | 2.7 | 7.8 | 46.1 | 25 | 15 | 15 | 6 | 14 | 40 | 0 | 22 | 2 | 0 | 0 | 2 | 0 | 4.00 |
| RP | Percival, T.Percival, Troy >> | 26 | 1995 | R | 82 | 34 | 0 | 1 | 2 | 6.05 | .310 | 1.32 | 7.8 | 4.3 | 8.8 | 38.2 | 33 | 28 | 26 | 9 | 18 | 37 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 5.63 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 74 | 28 | 0 | 0 | 1 | 2.77 | .345 | 1.58 | 8.3 | 5.9 | 8.0 | 26.0 | 24 | 12 | 8 | 2 | 17 | 23 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 4.19 |
| RP | Dotel, O.Dotel, Octavio >> | 29 | 2002 | R | 68 | 15 | 0 | 1 | 4 | 4.50 | .373 | 1.71 | 9.6 | 5.8 | 8.4 | 14.0 | 15 | 9 | 7 | 1 | 9 | 13 | 0 | 1 | 2 | 0 | 0 | 1 | 0 | 4.21 |
| RP | Messersmith, A.Messersmith, Andy >> | 23 | 1968 | R | 57 | 15 | 0 | 1 | 0 | 3.04 | .311 | 1.31 | 7.4 | 4.7 | 5.1 | 23.2 | 19 | 8 | 8 | 1 | 12 | 13 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 4.13 |
| SP | Lundgren, C.Lundgren, Carl >> | 27 | 1907 | R | 42 | 14 | 0 | 2 | 1 | 3.46 | .328 | 1.40 | 7.5 | 5.2 | 4.8 | 80.2 | 67 | 32 | 31 | 9 | 46 | 43 | 0 | 0 | 0 | 0 | 0 | 5 | 1 | 5.30 |