| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 25 | 25 | 9 | 11 | 3.06 | .266 | 1.07 | 7.9 | 1.8 | 9.1 | 167.2 | 146 | 60 | 57 | 22 | 34 | 169 | 1 | 0 | 0 | 0 | 20 | 2 | 0 | 3.34 |
| SP | Cole, G.Cole, Gerrit # >> | 28 | 2019 | R | 91 | 25 | 25 | 10 | 11 | 4.32 | .275 | 1.13 | 7.4 | 2.8 | 8.5 | 156.1 | 129 | 75 | 75 | 19 | 48 | 148 | 2 | 0 | 0 | 1 | 14 | 1 | 3 | 3.63 |
| SP | Ryan, N.Ryan, Nolan $$ >> | 44 | 1991 | R | 73 | 24 | 24 | 10 | 10 | 4.21 | .309 | 1.33 | 6.9 | 5.0 | 9.1 | 156.0 | 120 | 73 | 73 | 17 | 87 | 157 | 1 | 0 | 0 | 0 | 13 | 2 | 6 | 4.12 |
| SP | Sutton, D.Sutton, Don † >> | 27 | 1972 | R | 82 | 24 | 24 | 13 | 9 | 3.26 | .305 | 1.29 | 8.1 | 3.5 | 5.3 | 190.1 | 171 | 82 | 69 | 15 | 74 | 111 | 8 | 0 | 0 | 0 | 15 | 5 | 8 | 4.11 |
| SP | Reulbach, E.Reulbach, Ed >> | 24 | 1906 | R | 61 | 21 | 18 | 13 | 4 | 4.35 | .303 | 1.28 | 7.2 | 4.4 | 3.7 | 134.1 | 107 | 70 | 65 | 13 | 65 | 55 | 3 | 0 | 0 | 1 | 8 | 3 | 3 | 4.96 |
| RP | Devine, J.Devine, Joey >> | 25 | 2008 | R | 80 | 68 | 0 | 3 | 1 | 2.61 | .260 | 0.99 | 5.8 | 3.2 | 6.8 | 48.1 | 31 | 14 | 14 | 4 | 17 | 36 | 0 | 1 | 1 | 0 | 0 | 3 | 0 | 3.83 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 75 | 38 | 0 | 5 | 1 | 4.09 | .303 | 1.24 | 6.0 | 5.2 | 10.1 | 33.0 | 22 | 15 | 15 | 4 | 19 | 37 | 0 | 0 | 1 | 0 | 0 | 2 | 3 | 4.24 |
| RP | Perkins, G.Perkins, Glen >> | 30 | 2013 | L | 50 | 32 | 0 | 0 | 0 | 1.64 | .214 | 0.82 | 4.1 | 3.3 | 10.6 | 22.0 | 10 | 6 | 4 | 2 | 8 | 26 | 0 | 4 | 1 | 0 | 0 | 0 | 0 | 2.91 |
| RP | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 67 | 22 | 0 | 0 | 0 | 3.79 | .321 | 1.42 | 8.1 | 4.7 | 5.2 | 19.0 | 17 | 9 | 8 | 3 | 10 | 11 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 5.47 |
| CL | Chapman, A.Chapman, Aroldis † >> | 26 | 2014 | L | 93 | 37 | 0 | 1 | 3 | 3.93 | .275 | 1.14 | 7.1 | 3.2 | 10.3 | 34.1 | 27 | 18 | 15 | 4 | 12 | 39 | 0 | 25 | 3 | 0 | 0 | 0 | 1 | 3.29 |
| SP | Gooden, D.Gooden, Dwight >> | 21 | 1985 | R | 67 | 11 | 0 | 0 | 0 | 5.45 | .317 | 1.39 | 8.8 | 3.8 | 3.8 | 38.0 | 37 | 23 | 23 | 8 | 16 | 16 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 6.16 |