| SP | Scherzer, M.Scherzer, Max # >> | 33 | 2017 | R | 95 | 30 | 30 | 6 | 15 | 4.98 | .327 | 1.44 | 9.8 | 3.2 | 9.8 | 188.0 | 205 | 110 | 104 | 20 | 66 | 204 | 0 | 0 | 0 | 0 | 11 | 3 | 3 | 3.31 |
| SP | Hernandez, F.Hernandez, Felix >> | 28 | 2014 | R | 79 | 29 | 29 | 7 | 17 | 6.97 | .356 | 1.65 | 11.5 | 3.4 | 9.2 | 146.0 | 186 | 122 | 113 | 27 | 55 | 149 | 0 | 0 | 0 | 0 | 10 | 1 | 2 | 4.51 |
| SP | Bender, C.Bender, Chief >> | 26 | 1910 | R | 72 | 29 | 29 | 7 | 16 | 5.52 | .327 | 1.44 | 10.0 | 3.0 | 5.8 | 200.2 | 222 | 125 | 123 | 39 | 67 | 128 | 9 | 0 | 0 | 1 | 7 | 3 | 3 | 5.31 |
| SP | Chesbro, J.Chesbro, Jack # >> | 30 | 1904 | R | 65 | 29 | 29 | 9 | 16 | 5.12 | .324 | 1.43 | 10.5 | 2.4 | 5.0 | 204.0 | 237 | 121 | 116 | 19 | 55 | 114 | 8 | 0 | 0 | 3 | 10 | 1 | 5 | 3.92 |
| RP | Street, H.Street, Huston >> | 29 | 2012 | R | 96 | 73 | 0 | 3 | 3 | 3.75 | .323 | 1.41 | 7.8 | 5.0 | 8.4 | 98.1 | 85 | 44 | 41 | 8 | 54 | 92 | 0 | 8 | 0 | 0 | 0 | 2 | 2 | 3.90 |
| RP | Hochevar, L.Hochevar, Luke >> | 30 | 2013 | R | 78 | 70 | 0 | 2 | 2 | 3.40 | .287 | 1.18 | 7.5 | 3.1 | 10.0 | 92.2 | 77 | 41 | 35 | 4 | 32 | 102 | 0 | 6 | 4 | 0 | 0 | 3 | 6 | 2.49 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 64 | 61 | 0 | 4 | 3 | 6.65 | .366 | 1.68 | 8.6 | 6.6 | 9.1 | 70.1 | 67 | 58 | 52 | 6 | 51 | 71 | 0 | 3 | 2 | 0 | 0 | 4 | 5 | 4.44 |
| RP | Rodriguez, F.Rodriguez, Francisco >> | 22 | 2004 | R | 55 | 50 | 0 | 4 | 6 | 4.50 | .347 | 1.60 | 9.9 | 4.5 | 9.9 | 62.0 | 68 | 32 | 31 | 5 | 31 | 68 | 0 | 2 | 4 | 0 | 0 | 0 | 2 | 3.35 |
| SP | Coveleski, S.Coveleski, Stan >> | 28 | 1917 | R | 62 | 3 | 0 | 0 | 0 | 0.00 | .235 | 0.92 | 6.8 | 2.3 | 6.8 | 4.1 | 3 | 0 | 0 | 0 | 1 | 3 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.25 |
| SP | Hendricks, K.Hendricks, Kyle >> | 26 | 2016 | R | 55 | 41 | 0 | 3 | 3 | 5.11 | .353 | 1.61 | 10.6 | 4.1 | 5.9 | 75.2 | 88 | 55 | 43 | 10 | 34 | 49 | 0 | 2 | 2 | 0 | 0 | 2 | 3 | 4.87 |