| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 30 | 30 | 8 | 12 | 4.73 | .312 | 1.34 | 9.1 | 3.0 | 9.8 | 171.1 | 172 | 96 | 90 | 26 | 57 | 187 | 0 | 0 | 0 | 0 | 13 | 4 | 0 | 3.86 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 30 | 30 | 6 | 14 | 5.46 | .335 | 1.48 | 10.2 | 3.2 | 8.2 | 155.0 | 175 | 104 | 94 | 26 | 55 | 142 | 0 | 0 | 0 | 0 | 12 | 4 | 3 | 4.49 |
| SP | Nelson, R.Nelson, Roger >> | 28 | 1972 | R | 85 | 29 | 29 | 9 | 8 | 4.59 | .308 | 1.33 | 9.1 | 2.9 | 4.6 | 153.0 | 154 | 81 | 78 | 23 | 50 | 79 | 0 | 0 | 0 | 0 | 10 | 0 | 1 | 4.90 |
| SP | Krause, H.Krause, Harry >> | 21 | 1909 | L | 72 | 30 | 29 | 10 | 12 | 4.02 | .306 | 1.31 | 8.6 | 3.1 | 4.8 | 170.0 | 163 | 86 | 76 | 15 | 59 | 91 | 0 | 0 | 0 | 0 | 17 | 3 | 2 | 4.17 |
| SP | Drysdale, D.Drysdale, Don >> | 28 | 1964 | R | 59 | 28 | 28 | 6 | 12 | 6.70 | .358 | 1.63 | 11.1 | 3.6 | 4.9 | 147.2 | 182 | 118 | 110 | 24 | 58 | 80 | 2 | 0 | 0 | 0 | 8 | 7 | 4 | 5.36 |
| SU | Betances, D.Betances, Dellin >> | 26 | 2014 | R | 94 | 90 | 0 | 12 | 4 | 4.44 | .301 | 1.29 | 7.5 | 4.2 | 9.5 | 101.1 | 84 | 51 | 50 | 13 | 47 | 107 | 0 | 4 | 8 | 0 | 0 | 0 | 2 | 3.95 |
| CL | Gossage, R.Gossage, Rich >> | 30 | 1981 | R | 90 | 69 | 0 | 5 | 4 | 4.06 | .301 | 1.26 | 7.3 | 4.1 | 9.1 | 84.1 | 68 | 40 | 38 | 8 | 38 | 85 | 0 | 24 | 4 | 0 | 0 | 3 | 1 | 3.68 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 95 | 0 | 2 | 3 | 4.60 | .313 | 1.33 | 9.1 | 2.9 | 8.0 | 107.2 | 108 | 63 | 55 | 13 | 35 | 95 | 0 | 2 | 0 | 0 | 0 | 4 | 8 | 3.90 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 76 | 80 | 0 | 6 | 6 | 4.24 | .350 | 1.59 | 8.5 | 5.8 | 8.9 | 93.1 | 88 | 49 | 44 | 13 | 60 | 92 | 0 | 0 | 2 | 0 | 0 | 3 | 3 | 4.87 |