| SP | Martinez, P.Martinez, Pedro † >> | 29 | 2000 | R | 100 | 30 | 30 | 16 | 6 | 3.90 | .293 | 1.24 | 8.6 | 2.5 | 9.4 | 217.0 | 208 | 96 | 94 | 29 | 60 | 226 | 5 | 0 | 0 | 2 | 19 | 2 | 3 | 3.51 |
| SP | Cicotte, E.Cicotte, Eddie >> | 33 | 1917 | R | 74 | 28 | 28 | 12 | 11 | 4.55 | .336 | 1.51 | 9.7 | 3.9 | 4.3 | 188.0 | 203 | 104 | 95 | 22 | 81 | 90 | 2 | 0 | 0 | 1 | 13 | 2 | 0 | 4.89 |
| CL | Uehara, K.Uehara, Koji † >> | 38 | 2013 | R | 100 | 69 | 0 | 3 | 7 | 4.04 | .257 | 1.04 | 6.5 | 2.9 | 9.9 | 71.1 | 51 | 32 | 32 | 10 | 23 | 78 | 0 | 34 | 5 | 0 | 0 | 0 | 1 | 3.61 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 73 | 0 | 4 | 4 | 4.32 | .319 | 1.41 | 8.3 | 4.4 | 9.5 | 85.1 | 78 | 41 | 41 | 10 | 42 | 90 | 0 | 1 | 3 | 0 | 0 | 0 | 0 | 3.89 |
| RP | Pagan, E.Pagan, Emilio >> | 28 | 2019 | R | 77 | 40 | 0 | 2 | 2 | 5.02 | .328 | 1.47 | 10.0 | 3.1 | 9.8 | 43.0 | 48 | 24 | 24 | 10 | 15 | 47 | 0 | 2 | 2 | 0 | 0 | 0 | 0 | 4.88 |
| RP | Gregerson, L.Gregerson, Luke >> | 26 | 2010 | R | 73 | 35 | 0 | 0 | 2 | 4.11 | .289 | 1.22 | 7.0 | 3.9 | 7.8 | 46.0 | 36 | 21 | 21 | 3 | 20 | 40 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 3.41 |
| SP | Clemens, R.Clemens, Roger >> | 24 | 1986 | R | 69 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Marichal, J.Marichal, Juan >> | 29 | 1966 | R | 77 | 15 | 0 | 0 | 2 | 4.26 | .276 | 1.11 | 8.6 | 1.4 | 4.3 | 25.1 | 24 | 12 | 12 | 4 | 4 | 12 | 0 | 3 | 0 | 0 | 0 | 1 | 0 | 4.72 |