| SP | Skubal, T.Skubal, Tarik >> | 28 | 2025 | L | 100 | 11 | 11 | 3 | 3 | 3.12 | .311 | 1.27 | 8.0 | 3.4 | 11.2 | 66.1 | 59 | 23 | 23 | 5 | 25 | 82 | 0 | 0 | 0 | 0 | 7 | 6 | 2 | 2.91 |
| SP | deGrom, J.deGrom, Jacob $$ >> | 37 | 2025 | R | 98 | 11 | 11 | 5 | 3 | 3.92 | .272 | 1.09 | 7.7 | 2.1 | 11.7 | 64.1 | 55 | 28 | 28 | 9 | 15 | 83 | 0 | 0 | 0 | 0 | 7 | 2 | 4 | 3.03 |
| SP | Gausman, K.Gausman, Kevin >> | 34 | 2025 | R | 84 | 11 | 11 | 3 | 4 | 3.49 | .321 | 1.38 | 8.9 | 3.7 | 7.6 | 69.2 | 68 | 28 | 27 | 7 | 28 | 58 | 0 | 0 | 0 | 0 | 7 | 3 | 0 | 3.99 |
| SP | Sanchez, C.Sanchez, Cristopher >> | 28 | 2025 | L | 82 | 11 | 11 | 4 | 7 | 3.17 | .319 | 1.38 | 9.4 | 3.0 | 11.2 | 65.1 | 68 | 25 | 23 | 4 | 22 | 81 | 0 | 0 | 0 | 0 | 7 | 2 | 0 | 2.42 |
| SP | Cabrera, E.Cabrera, Edward >> | 27 | 2025 | R | 69 | 10 | 10 | 5 | 3 | 4.89 | .344 | 1.53 | 10.3 | 3.7 | 8.4 | 49.2 | 56 | 27 | 27 | 7 | 20 | 46 | 0 | 0 | 0 | 0 | 4 | 2 | 1 | 4.33 |
| RP | Kittredge, A.Kittredge, Andrew >> | 35 | 2025 | R | 84 | 35 | 0 | 0 | 0 | 1.91 | .267 | 1.06 | 7.4 | 2.3 | 9.6 | 28.1 | 23 | 6 | 6 | 2 | 7 | 30 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 2.64 |
| RP | Miller, S.Miller, Shelby >> | 34 | 2025 | R | 83 | 33 | 0 | 1 | 1 | 2.79 | .223 | 0.86 | 5.3 | 2.5 | 10.6 | 29.0 | 17 | 9 | 9 | 2 | 8 | 34 | 0 | 6 | 1 | 0 | 0 | 0 | 1 | 2.38 |
| RP | Sousa, B.Sousa, Bennett >> | 30 | 2025 | L | 80 | 41 | 0 | 2 | 1 | 2.60 | .245 | 0.94 | 7.0 | 1.7 | 6.7 | 27.2 | 21 | 8 | 8 | 1 | 5 | 20 | 0 | 2 | 0 | 0 | 0 | 1 | 2 | 2.67 |
| RP | Estevez, C.Estevez, Carlos >> | 32 | 2025 | R | 69 | 21 | 0 | 1 | 3 | 7.02 | .351 | 1.56 | 10.7 | 3.9 | 7.9 | 16.2 | 19 | 13 | 13 | 3 | 7 | 14 | 0 | 0 | 2 | 0 | 0 | 1 | 1 | 5.19 |
| RP | Phillips, T.Phillips, Tyler >> | 27 | 2025 | R | 55 | 18 | 0 | 1 | 2 | 2.50 | .316 | 1.39 | 9.0 | 3.5 | 8.0 | 18.0 | 18 | 5 | 5 | 2 | 7 | 16 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 3.83 |
| RP | Stewart, B.Stewart, Brock >> | 33 | 2025 | R | 53 | 18 | 0 | 0 | 1 | 2.05 | .290 | 1.18 | 7.0 | 3.7 | 10.6 | 22.0 | 17 | 5 | 5 | 1 | 9 | 26 | 0 | 2 | 0 | 0 | 0 | 1 | 0 | 2.59 |