| SP | Kershaw, C.Kershaw, Clayton >> | 28 | 2016 | L | 99 | 34 | 34 | 13 | 17 | 4.33 | .288 | 1.20 | 9.5 | 1.4 | 8.4 | 232.2 | 244 | 117 | 112 | 21 | 36 | 217 | 4 | 0 | 0 | 0 | 19 | 2 | 6 | 2.80 |
| SP | Cole, G.Cole, Gerrit # >> | 28 | 2019 | R | 92 | 33 | 33 | 10 | 15 | 5.75 | .333 | 1.47 | 10.4 | 2.8 | 9.6 | 187.2 | 217 | 121 | 120 | 23 | 59 | 199 | 0 | 0 | 0 | 0 | 11 | 5 | 5 | 3.50 |
| SP | Nelson, R.Nelson, Roger >> | 28 | 1972 | R | 85 | 32 | 32 | 7 | 16 | 5.90 | .332 | 1.49 | 10.2 | 3.1 | 4.8 | 183.0 | 208 | 125 | 120 | 27 | 64 | 98 | 0 | 0 | 0 | 0 | 9 | 1 | 1 | 4.91 |
| SP | Brown, M.Brown, Mordecai >> | 32 | 1908 | R | 85 | 32 | 32 | 12 | 7 | 4.82 | .334 | 1.48 | 10.7 | 2.7 | 4.4 | 220.1 | 262 | 120 | 118 | 25 | 65 | 107 | 3 | 0 | 0 | 1 | 11 | 4 | 3 | 4.45 |
| CL | Uehara, K.Uehara, Koji >> | 38 | 2013 | R | 100 | 49 | 0 | 2 | 5 | 4.60 | .316 | 1.38 | 8.8 | 3.6 | 6.1 | 47.0 | 46 | 29 | 24 | 5 | 19 | 32 | 0 | 29 | 6 | 0 | 0 | 0 | 1 | 4.23 |
| SU | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 59 | 0 | 3 | 4 | 4.05 | .308 | 1.30 | 8.4 | 3.3 | 7.2 | 60.0 | 56 | 31 | 27 | 8 | 22 | 48 | 0 | 0 | 2 | 0 | 0 | 2 | 0 | 4.33 |
| RP | Capps, C.Capps, Carter >> | 24 | 2015 | R | 84 | 77 | 0 | 3 | 3 | 3.69 | .309 | 1.34 | 8.5 | 3.6 | 10.9 | 90.1 | 85 | 40 | 37 | 8 | 36 | 109 | 0 | 1 | 4 | 0 | 0 | 0 | 5 | 2.93 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 76 | 36 | 0 | 2 | 1 | 3.92 | .299 | 1.26 | 8.3 | 3.0 | 6.7 | 39.0 | 36 | 22 | 17 | 4 | 13 | 29 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 3.92 |
| RP | Gregerson, L.Gregerson, Luke >> | 26 | 2010 | R | 73 | 34 | 0 | 1 | 0 | 5.54 | .354 | 1.62 | 12.5 | 2.1 | 7.8 | 39.0 | 54 | 27 | 24 | 3 | 9 | 34 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 3.03 |