| SP | Mathewson, C.Mathewson, Christy † >> | 28 | 1908 | R | 83 | 32 | 32 | 23 | 5 | 2.73 | .265 | 1.05 | 7.5 | 2.0 | 4.7 | 250.2 | 207 | 84 | 76 | 20 | 56 | 131 | 9 | 0 | 0 | 1 | 24 | 8 | 3 | 3.76 |
| SP | Cueto, J.Cueto, Johnny # >> | 28 | 2014 | R | 75 | 32 | 32 | 11 | 12 | 5.02 | .321 | 1.39 | 9.0 | 3.6 | 6.6 | 202.2 | 201 | 119 | 113 | 27 | 81 | 149 | 4 | 0 | 0 | 1 | 14 | 5 | 2 | 4.54 |
| RP | Street, H.Street, Huston >> | 29 | 2012 | R | 96 | 80 | 0 | 6 | 5 | 3.46 | .316 | 1.36 | 6.7 | 5.5 | 7.5 | 91.0 | 68 | 40 | 35 | 8 | 56 | 76 | 0 | 12 | 4 | 0 | 0 | 2 | 3 | 4.38 |
| RP | Clippard, T.Clippard, Tyler >> | 26 | 2011 | R | 79 | 65 | 0 | 2 | 5 | 2.75 | .280 | 1.17 | 6.0 | 4.6 | 8.3 | 75.1 | 50 | 25 | 23 | 7 | 38 | 69 | 0 | 11 | 2 | 0 | 0 | 0 | 3 | 3.89 |
| RP | Bailey, A.Bailey, Andrew >> | 25 | 2009 | R | 67 | 42 | 0 | 1 | 2 | 2.45 | .267 | 1.09 | 6.7 | 3.3 | 8.2 | 47.2 | 35 | 15 | 13 | 6 | 17 | 43 | 0 | 3 | 0 | 0 | 0 | 0 | 1 | 3.91 |
| RP | Messersmith, A.Messersmith, Andy >> | 23 | 1968 | R | 58 | 36 | 0 | 6 | 4 | 3.46 | .306 | 1.31 | 6.2 | 5.5 | 6.0 | 65.0 | 45 | 29 | 25 | 9 | 40 | 43 | 0 | 1 | 2 | 0 | 0 | 1 | 3 | 5.37 |
| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 61 | 1 | 0 | 0 | 0 | 0.00 | .333 | 1.50 | 9.0 | 9.0 | 0.0 | 1.1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 6.00 |
| SP | Liriano, F.Liriano, Francisco >> | 23 | 2006 | L | 58 | 22 | 0 | 2 | 2 | 6.19 | .347 | 1.56 | 11.0 | 3.1 | 8.7 | 32.0 | 39 | 22 | 22 | 11 | 11 | 31 | 0 | 5 | 3 | 0 | 0 | 1 | 1 | 6.66 |