| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 27 | 27 | 13 | 7 | 3.36 | .278 | 1.15 | 7.7 | 2.6 | 9.5 | 182.0 | 156 | 70 | 68 | 21 | 53 | 193 | 1 | 0 | 0 | 0 | 20 | 1 | 0 | 3.27 |
| SP | Kluber, C.Kluber, Corey # >> | 31 | 2017 | R | 89 | 26 | 26 | 6 | 15 | 5.29 | .323 | 1.41 | 9.8 | 2.9 | 8.0 | 182.0 | 198 | 116 | 107 | 24 | 58 | 161 | 2 | 0 | 0 | 1 | 10 | 5 | 3 | 3.98 |
| SP | Nelson, R.Nelson, Roger # >> | 28 | 1972 | R | 84 | 26 | 26 | 5 | 11 | 6.50 | .332 | 1.47 | 10.5 | 2.8 | 5.5 | 133.0 | 155 | 98 | 96 | 21 | 41 | 81 | 0 | 0 | 0 | 0 | 5 | 2 | 0 | 4.80 |
| SP | McLain, D.McLain, Denny # >> | 24 | 1968 | R | 78 | 26 | 26 | 10 | 11 | 4.43 | .322 | 1.41 | 10.5 | 2.1 | 6.0 | 201.0 | 235 | 100 | 99 | 33 | 48 | 133 | 12 | 0 | 0 | 1 | 11 | 3 | 2 | 4.57 |
| SP | Liriano, F.Liriano, Francisco # >> | 23 | 2006 | L | 58 | 23 | 23 | 4 | 10 | 4.90 | .325 | 1.42 | 8.7 | 4.0 | 7.7 | 101.0 | 98 | 63 | 55 | 13 | 45 | 86 | 1 | 0 | 0 | 1 | 3 | 3 | 5 | 4.40 |
| RP | Saito, T.Saito, Takashi >> | 37 | 2007 | R | 91 | 58 | 0 | 2 | 1 | 2.14 | .317 | 1.37 | 7.7 | 4.8 | 9.5 | 54.2 | 46 | 15 | 13 | 5 | 29 | 57 | 0 | 7 | 1 | 0 | 0 | 1 | 0 | 3.76 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 78 | 62 | 0 | 2 | 4 | 5.40 | .333 | 1.48 | 8.3 | 5.0 | 9.0 | 40.0 | 37 | 27 | 24 | 6 | 22 | 40 | 0 | 3 | 2 | 0 | 0 | 1 | 6 | 4.68 |
| RP | Benitez, A.Benitez, Armando # >> | 32 | 2004 | R | 81 | 50 | 0 | 4 | 6 | 7.12 | .371 | 1.74 | 10.7 | 5.0 | 7.1 | 43.0 | 51 | 35 | 34 | 10 | 24 | 34 | 0 | 5 | 6 | 0 | 0 | 1 | 0 | 6.19 |
| RP | Holland, G.Holland, Greg # >> | 27 | 2013 | R | 71 | 30 | 0 | 1 | 2 | 7.55 | .388 | 1.87 | 11.9 | 4.9 | 9.0 | 31.0 | 41 | 27 | 26 | 3 | 17 | 31 | 0 | 3 | 2 | 0 | 0 | 1 | 1 | 4.00 |
| RP | Urbina, U.Urbina, Ugueth >> | 24 | 1998 | R | 58 | 25 | 0 | 1 | 1 | 7.40 | .360 | 1.64 | 9.4 | 5.6 | 9.4 | 24.1 | 25 | 23 | 20 | 5 | 15 | 25 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 5.63 |