| SP | Koufax, S.Koufax, Sandy >> | 30 | 1965 | L | 98 | 27 | 27 | 12 | 8 | 3.67 | .264 | 1.06 | 7.0 | 2.5 | 8.1 | 203.2 | 159 | 83 | 83 | 21 | 57 | 183 | 5 | 0 | 0 | 0 | 15 | 3 | 3 | 3.43 |
| SP | Alexander, P.Alexander, Pete >> | 28 | 1915 | R | 88 | 27 | 27 | 11 | 10 | 3.89 | .287 | 1.19 | 8.7 | 2.0 | 4.1 | 205.2 | 198 | 94 | 89 | 17 | 46 | 93 | 6 | 0 | 0 | 2 | 17 | 4 | 4 | 3.90 |
| SP | Lincecum, T.Lincecum, Tim # >> | 25 | 2009 | R | 39 | 20 | 20 | 9 | 7 | 4.47 | .311 | 1.35 | 8.9 | 3.3 | 8.3 | 131.0 | 129 | 67 | 65 | 14 | 48 | 121 | 2 | 0 | 0 | 0 | 10 | 0 | 5 | 3.64 |
| SP | Pfiester, J.Pfiester, Jack >> | 28 | 1906 | L | 73 | 26 | 26 | 10 | 11 | 4.46 | .313 | 1.35 | 8.5 | 3.7 | 4.6 | 179.2 | 170 | 96 | 89 | 18 | 73 | 92 | 8 | 0 | 0 | 0 | 13 | 2 | 3 | 4.54 |
| SU | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 63 | 38 | 0 | 3 | 0 | 1.62 | .253 | 1.02 | 5.7 | 3.5 | 9.0 | 44.1 | 28 | 10 | 8 | 0 | 17 | 44 | 0 | 4 | 4 | 0 | 0 | 0 | 1 | 2.16 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 75 | 30 | 0 | 3 | 2 | 3.13 | .275 | 1.11 | 7.0 | 3.2 | 11.0 | 31.2 | 24 | 11 | 11 | 4 | 11 | 38 | 0 | 2 | 1 | 0 | 0 | 1 | 2 | 3.39 |
| RP | Chapman, A.Chapman, Aroldis >> | 26 | 2014 | L | 93 | 27 | 0 | 0 | 2 | 3.45 | .312 | 1.36 | 8.7 | 3.9 | 9.6 | 28.2 | 27 | 12 | 11 | 1 | 12 | 30 | 0 | 6 | 3 | 0 | 0 | 0 | 1 | 2.61 |
| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 84 | 8 | 6 | 3 | 2 | 5.44 | .304 | 1.29 | 9.2 | 2.6 | 8.3 | 49.2 | 50 | 30 | 30 | 6 | 14 | 45 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 3.67 |
| SP | McDowell, S.McDowell, Sam >> | 23 | 1965 | L | 44 | 11 | 0 | 2 | 1 | 2.55 | .278 | 1.16 | 7.0 | 3.5 | 6.1 | 49.1 | 38 | 14 | 14 | 1 | 19 | 33 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 3.08 |