| SP | Kershaw, C.Kershaw, Clayton >> | 28 | 2016 | L | 99 | 38 | 38 | 14 | 14 | 3.50 | .276 | 1.13 | 8.6 | 1.6 | 7.1 | 272.1 | 259 | 115 | 106 | 30 | 49 | 214 | 6 | 0 | 0 | 0 | 24 | 4 | 7 | 3.44 |
| SP | Leonard, D.Leonard, Dutch † >> | 22 | 1914 | L | 91 | 37 | 37 | 16 | 11 | 3.39 | .290 | 1.21 | 7.0 | 3.9 | 5.4 | 230.2 | 179 | 90 | 87 | 13 | 100 | 139 | 1 | 0 | 0 | 1 | 25 | 4 | 4 | 3.88 |
| SP | Newhouser, H.Newhouser, Hal >> | 25 | 1946 | L | 30 | 25 | 25 | 10 | 11 | 4.41 | .307 | 1.32 | 8.2 | 3.7 | 5.5 | 163.1 | 148 | 83 | 80 | 14 | 67 | 99 | 3 | 0 | 0 | 1 | 14 | 2 | 3 | 4.17 |
| SP | Hunter, C.Hunter, Catfish >> | 26 | 1972 | R | 81 | 35 | 35 | 19 | 13 | 3.59 | .295 | 1.23 | 8.2 | 2.8 | 4.5 | 248.1 | 227 | 110 | 99 | 21 | 78 | 124 | 9 | 0 | 0 | 2 | 20 | 7 | 3 | 4.13 |
| CL | Doolittle, S.Doolittle, Sean † >> | 31 | 2018 | L | 99 | 73 | 0 | 6 | 7 | 3.39 | .245 | 0.96 | 6.2 | 2.5 | 9.8 | 77.0 | 53 | 29 | 29 | 10 | 21 | 84 | 0 | 45 | 7 | 0 | 0 | 1 | 0 | 3.36 |
| RP | Drabowsky, M.Drabowsky, Moe >> | 31 | 1966 | R | 53 | 74 | 0 | 10 | 1 | 3.99 | .302 | 1.28 | 7.5 | 4.1 | 7.4 | 85.2 | 71 | 39 | 38 | 7 | 39 | 70 | 0 | 1 | 3 | 0 | 0 | 1 | 0 | 3.84 |
| RP | Holland, G.Holland, Greg >> | 27 | 2013 | R | 71 | 41 | 0 | 3 | 1 | 1.76 | .245 | 0.98 | 5.9 | 2.9 | 6.6 | 41.0 | 27 | 8 | 8 | 3 | 13 | 30 | 0 | 4 | 0 | 0 | 0 | 0 | 2 | 3.44 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 63 | 22 | 0 | 0 | 1 | 3.10 | .281 | 1.17 | 7.4 | 3.1 | 6.8 | 29.0 | 24 | 10 | 10 | 4 | 10 | 22 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 4.31 |
| SP | Schilling, C.Schilling, Curt # >> | 36 | 2002 | R | 49 | 11 | 5 | 1 | 2 | 5.11 | .327 | 1.42 | 9.6 | 3.2 | 8.8 | 56.1 | 60 | 33 | 32 | 5 | 20 | 55 | 0 | 0 | 0 | 0 | 2 | 2 | 0 | 3.38 |
| SP | Lincecum, T.Lincecum, Tim >> | 25 | 2009 | R | 39 | 8 | 0 | 1 | 0 | 4.96 | .329 | 1.41 | 10.4 | 2.5 | 6.2 | 32.2 | 37 | 18 | 18 | 4 | 9 | 22 | 0 | 0 | 0 | 0 | 0 | 2 | 1 | 4.28 |