| SP | Koufax, S.Koufax, Sandy >> | 30 | 1965 | L | 98 | 34 | 34 | 12 | 15 | 4.20 | .314 | 1.36 | 9.5 | 2.8 | 8.4 | 261.2 | 275 | 134 | 122 | 33 | 80 | 244 | 9 | 0 | 0 | 1 | 16 | 4 | 6 | 3.74 |
| SP | Adams, B.Adams, Babe # >> | 27 | 1909 | R | 86 | 33 | 33 | 9 | 10 | 5.25 | .323 | 1.43 | 10.0 | 2.9 | 4.3 | 180.0 | 200 | 107 | 105 | 26 | 57 | 86 | 0 | 0 | 0 | 0 | 13 | 1 | 7 | 4.89 |
| SP | Pfiester, J.Pfiester, Jack >> | 28 | 1906 | L | 73 | 32 | 32 | 8 | 17 | 5.21 | .350 | 1.60 | 10.2 | 4.2 | 5.3 | 231.1 | 262 | 151 | 134 | 33 | 108 | 136 | 9 | 0 | 0 | 1 | 12 | 4 | 4 | 5.13 |
| SP | Caldwell, R.Caldwell, Ray >> | 26 | 1914 | R | 64 | 32 | 32 | 8 | 18 | 5.77 | .366 | 1.70 | 11.7 | 3.6 | 5.2 | 184.0 | 239 | 130 | 118 | 22 | 74 | 107 | 0 | 0 | 0 | 0 | 16 | 5 | 4 | 4.68 |
| RP | Feliz, N.Feliz, Neftali >> | 21 | 2009 | R | 97 | 80 | 0 | 1 | 5 | 3.35 | .291 | 1.23 | 6.7 | 4.5 | 8.5 | 96.2 | 71 | 39 | 36 | 8 | 48 | 91 | 0 | 3 | 4 | 0 | 0 | 0 | 0 | 3.69 |
| RP | Eckersley, D.Eckersley, Dennis # >> | 36 | 1990 | R | 87 | 80 | 0 | 5 | 7 | 4.72 | .325 | 1.41 | 9.5 | 3.1 | 8.3 | 103.0 | 109 | 56 | 54 | 12 | 36 | 95 | 0 | 4 | 5 | 0 | 0 | 4 | 0 | 3.83 |
| RP | Gregerson, L.Gregerson, Luke >> | 26 | 2010 | R | 73 | 80 | 0 | 4 | 5 | 3.76 | .300 | 1.29 | 9.0 | 2.6 | 8.6 | 91.0 | 91 | 40 | 38 | 13 | 26 | 87 | 0 | 14 | 3 | 0 | 0 | 0 | 0 | 3.80 |
| RP | Rodriguez, F.Rodriguez, Francisco >> | 22 | 2004 | R | 55 | 38 | 0 | 2 | 2 | 3.58 | .294 | 1.21 | 7.0 | 4.0 | 7.9 | 50.1 | 39 | 20 | 20 | 3 | 22 | 44 | 0 | 2 | 0 | 0 | 0 | 2 | 0 | 3.46 |
| SP | Harden, R.Harden, Rich >> | 27 | 2008 | R | 60 | 13 | 0 | 3 | 1 | 4.11 | .343 | 1.57 | 9.0 | 5.4 | 9.6 | 15.1 | 15 | 7 | 7 | 3 | 9 | 16 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 5.27 |