| SP | Richard, J.Richard, J.R. >> | 30 | 1980 | R | 90 | 33 | 33 | 10 | 10 | 4.18 | .321 | 1.40 | 8.5 | 4.1 | 6.8 | 196.0 | 185 | 95 | 91 | 17 | 89 | 149 | 2 | 0 | 0 | 1 | 21 | 4 | 7 | 4.03 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 34 | 34 | 7 | 19 | 5.86 | .324 | 1.42 | 9.5 | 3.2 | 8.9 | 167.1 | 177 | 123 | 109 | 29 | 60 | 165 | 1 | 0 | 0 | 1 | 12 | 4 | 4 | 4.43 |
| SP | Mathewson, C.Mathewson, Christy >> | 28 | 1908 | R | 83 | 32 | 32 | 9 | 11 | 5.18 | .319 | 1.37 | 10.6 | 1.7 | 4.7 | 170.1 | 201 | 106 | 98 | 18 | 33 | 89 | 2 | 0 | 0 | 1 | 16 | 5 | 3 | 4.00 |
| SP | Marichal, J.Marichal, Juan >> | 29 | 1966 | R | 77 | 32 | 32 | 5 | 15 | 6.96 | .363 | 1.68 | 12.3 | 2.9 | 4.6 | 160.1 | 218 | 147 | 124 | 34 | 51 | 81 | 4 | 0 | 0 | 0 | 8 | 5 | 2 | 5.80 |
| SP | Scherzer, M.Scherzer, Max # >> | 33 | 2017 | R | 95 | 31 | 31 | 8 | 11 | 4.40 | .294 | 1.22 | 8.2 | 2.8 | 9.2 | 176.0 | 160 | 90 | 86 | 24 | 55 | 179 | 1 | 0 | 0 | 0 | 17 | 5 | 1 | 3.76 |
| SU | Chapman, A.Chapman, Aroldis >> | 26 | 2014 | L | 94 | 80 | 0 | 2 | 2 | 2.76 | .246 | 0.97 | 4.5 | 4.2 | 9.6 | 98.0 | 49 | 31 | 30 | 8 | 46 | 104 | 0 | 3 | 6 | 0 | 0 | 1 | 2 | 3.38 |
| CL | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 83 | 0 | 6 | 11 | 5.76 | .340 | 1.51 | 10.3 | 3.4 | 7.5 | 104.2 | 119 | 71 | 67 | 13 | 39 | 87 | 0 | 8 | 10 | 0 | 0 | 4 | 1 | 4.19 |
| RP | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 85 | 89 | 0 | 3 | 5 | 5.42 | .352 | 1.58 | 10.3 | 4.0 | 8.0 | 89.2 | 102 | 60 | 54 | 8 | 40 | 79 | 0 | 5 | 6 | 0 | 0 | 4 | 0 | 3.88 |
| RP | Gallegos, G.Gallegos, Giovanny † >> | 27 | 2019 | R | 82 | 80 | 0 | 8 | 1 | 3.50 | .287 | 1.20 | 7.9 | 3.0 | 9.2 | 97.2 | 85 | 39 | 38 | 16 | 32 | 99 | 0 | 5 | 2 | 0 | 0 | 1 | 2 | 4.12 |
| RP | Sutter, B.Sutter, Bruce >> | 24 | 1977 | R | 68 | 70 | 0 | 4 | 1 | 4.50 | .328 | 1.45 | 9.1 | 3.9 | 8.0 | 80.0 | 81 | 41 | 40 | 9 | 35 | 71 | 0 | 2 | 0 | 0 | 0 | 1 | 7 | 4.04 |
| SP | Gooden, D.Gooden, Dwight >> | 21 | 1985 | R | 68 | 1 | 0 | 0 | 0 | 13.50 | .500 | 3.00 | - | - | - | 0.2 | 2 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Halladay, R.Halladay, Roy >> | 28 | 2005 | R | 48 | 10 | 0 | 1 | 2 | 1.71 | .284 | 1.19 | 9.0 | 1.7 | 3.4 | 21.0 | 21 | 7 | 4 | 0 | 4 | 8 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 2.81 |