| SP | Martinez, P.Martinez, Pedro >> | 29 | 2000 | R | 100 | 13 | 13 | 8 | 4 | 3.11 | .283 | 1.15 | 7.9 | 2.5 | 7.8 | 101.1 | 89 | 38 | 35 | 7 | 28 | 87 | 4 | 0 | 0 | 1 | 9 | 3 | 2 | 3.10 |
| SP | Kluber, C.Kluber, Corey >> | 31 | 2017 | R | 90 | 12 | 12 | 6 | 6 | 5.38 | .323 | 1.41 | 10.1 | 2.6 | 9.8 | 75.1 | 84 | 51 | 45 | 10 | 22 | 82 | 0 | 0 | 0 | 0 | 6 | 2 | 2 | 3.51 |
| SP | Nelson, R.Nelson, Roger >> | 28 | 1972 | R | 85 | 12 | 12 | 2 | 3 | 5.31 | .341 | 1.55 | 11.1 | 2.9 | 5.8 | 59.1 | 73 | 40 | 35 | 14 | 19 | 38 | 0 | 0 | 0 | 0 | 2 | 0 | 1 | 5.76 |
| SP | Guidry, R.Guidry, Ron # >> | 28 | 1978 | L | 78 | 12 | 12 | 7 | 2 | 4.64 | .296 | 1.26 | 8.5 | 2.9 | 6.4 | 87.1 | 82 | 46 | 45 | 5 | 28 | 62 | 2 | 0 | 0 | 0 | 6 | 0 | 2 | 3.29 |
| CL | Jansen, K.Jansen, Kenley >> | 28 | 2016 | R | 97 | 26 | 0 | 4 | 3 | 3.91 | .337 | 1.48 | 8.2 | 5.1 | 8.2 | 23.0 | 21 | 10 | 10 | 3 | 13 | 21 | 0 | 12 | 1 | 0 | 0 | 1 | 0 | 4.70 |
| SU | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 94 | 25 | 0 | 1 | 1 | 5.93 | .322 | 1.39 | 8.0 | 4.7 | 9.0 | 27.1 | 24 | 18 | 18 | 6 | 14 | 27 | 0 | 0 | 3 | 0 | 0 | 1 | 0 | 5.56 |
| RP | Gallegos, G.Gallegos, Giovanny >> | 27 | 2019 | R | 82 | 28 | 0 | 3 | 1 | 3.93 | .335 | 1.51 | 10.9 | 2.9 | 10.1 | 34.1 | 41 | 15 | 15 | 5 | 11 | 38 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 3.65 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 76 | 24 | 0 | 2 | 1 | 2.96 | .255 | 0.99 | 7.7 | 1.3 | 7.0 | 27.1 | 23 | 9 | 9 | 3 | 4 | 21 | 0 | 2 | 3 | 0 | 0 | 1 | 0 | 3.44 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 75 | 21 | 0 | 0 | 0 | 4.15 | .270 | 1.11 | 4.7 | 5.6 | 12.9 | 21.2 | 11 | 11 | 10 | 0 | 13 | 30 | 0 | 1 | 0 | 0 | 0 | 0 | 4 | 2.00 |
| SP | Gooden, D.Gooden, Dwight >> | 21 | 1985 | R | 68 | 9 | 0 | 1 | 1 | 4.63 | .360 | 1.63 | 10.3 | 4.4 | 8.5 | 35.0 | 40 | 20 | 18 | 4 | 17 | 33 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 4.23 |