| SP | Johnson, W.Johnson, Walter >> | 26 | 1913 | R | 95 | 27 | 27 | 8 | 14 | 5.66 | .325 | 1.44 | 10.8 | 2.2 | 5.7 | 163.2 | 196 | 105 | 103 | 18 | 40 | 104 | 2 | 0 | 0 | 1 | 10 | 0 | 5 | 3.90 |
| SP | Scherzer, M.Scherzer, Max >> | 33 | 2017 | R | 95 | 28 | 28 | 11 | 12 | 4.08 | .320 | 1.38 | 8.5 | 4.0 | 10.0 | 176.1 | 166 | 85 | 80 | 20 | 78 | 195 | 1 | 0 | 0 | 0 | 14 | 5 | 4 | 3.68 |
| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 84 | 28 | 28 | 8 | 10 | 5.71 | .350 | 1.60 | 11.1 | 3.4 | 8.8 | 171.2 | 211 | 110 | 109 | 24 | 64 | 168 | 2 | 0 | 0 | 0 | 9 | 2 | 4 | 4.02 |
| SP | McLain, D.McLain, Denny >> | 24 | 1968 | R | 78 | 27 | 27 | 11 | 9 | 4.16 | .326 | 1.43 | 9.4 | 3.5 | 6.1 | 188.1 | 196 | 95 | 87 | 21 | 73 | 127 | 6 | 0 | 0 | 0 | 16 | 4 | 1 | 4.33 |
| CL | Uehara, K.Uehara, Koji >> | 38 | 2013 | R | 100 | 57 | 0 | 1 | 7 | 3.30 | .304 | 1.29 | 7.4 | 4.3 | 8.2 | 57.1 | 47 | 22 | 21 | 2 | 27 | 52 | 0 | 32 | 2 | 0 | 0 | 1 | 0 | 3.11 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 72 | 0 | 2 | 4 | 3.44 | .264 | 1.04 | 5.9 | 3.6 | 8.4 | 96.2 | 63 | 37 | 37 | 12 | 38 | 90 | 0 | 4 | 3 | 0 | 0 | 3 | 0 | 4.03 |
| RP | Capps, C.Capps, Carter >> | 24 | 2015 | R | 84 | 60 | 0 | 4 | 3 | 3.91 | .321 | 1.41 | 8.5 | 4.2 | 9.0 | 69.0 | 65 | 35 | 30 | 4 | 32 | 69 | 0 | 2 | 1 | 0 | 0 | 1 | 3 | 3.19 |
| RP | Percival, T.Percival, Troy >> | 26 | 1995 | R | 82 | 25 | 0 | 3 | 0 | 3.72 | .275 | 1.07 | 5.9 | 3.7 | 9.9 | 29.0 | 19 | 12 | 12 | 4 | 12 | 32 | 0 | 1 | 0 | 0 | 0 | 2 | 1 | 4.03 |