| SP | Verlander, J.Verlander, Justin † >> | 36 | 2019 | R | 99 | 36 | 36 | 25 | 9 | 2.51 | .234 | 0.90 | 6.0 | 2.2 | 7.6 | 272.1 | 181 | 81 | 76 | 20 | 65 | 231 | 10 | 0 | 0 | 3 | 29 | 3 | 3 | 3.01 |
| SP | Lundgren, C.Lundgren, Carl >> | 27 | 1907 | R | 42 | 31 | 29 | 11 | 9 | 2.68 | .298 | 1.25 | 6.7 | 4.5 | 3.6 | 198.1 | 148 | 59 | 59 | 13 | 100 | 80 | 2 | 0 | 0 | 1 | 20 | 4 | 1 | 4.62 |
| SP | Coombs, J.Coombs, Jack >> | 28 | 1910 | R | 43 | 32 | 30 | 12 | 7 | 3.29 | .289 | 1.20 | 7.6 | 3.3 | 4.5 | 180.1 | 151 | 68 | 66 | 12 | 65 | 90 | 2 | 1 | 0 | 1 | 19 | 4 | 4 | 4.02 |
| RP | Adams, M.Adams, Mike † >> | 31 | 2009 | R | 99 | 99 | 0 | 14 | 1 | 1.61 | .216 | 0.83 | 4.1 | 3.3 | 7.5 | 100.1 | 46 | 18 | 18 | 5 | 37 | 83 | 0 | 7 | 0 | 0 | 0 | 0 | 1 | 3.10 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 63 | 63 | 0 | 1 | 4 | 4.08 | .270 | 1.08 | 6.0 | 3.9 | 8.1 | 39.2 | 26 | 18 | 18 | 4 | 17 | 35 | 0 | 4 | 4 | 0 | 0 | 1 | 2 | 3.92 |
| RP | Rocker, J.Rocker, John # >> | 24 | 1998 | L | 33 | 49 | 0 | 1 | 2 | 5.11 | .311 | 1.32 | 5.6 | 6.3 | 5.8 | 37.0 | 23 | 21 | 21 | 3 | 26 | 24 | 0 | 5 | 1 | 0 | 0 | 1 | 1 | 4.95 |
| RP | Broxton, J.Broxton, Jonathan >> | 25 | 2009 | R | 62 | 10 | 0 | 1 | 1 | 4.15 | .366 | 1.62 | 7.9 | 7.9 | 6.8 | 8.2 | 7 | 4 | 4 | 0 | 7 | 6 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 4.50 |
| RP | LaRoche, D.LaRoche, Dave >> | 28 | 1976 | L | 30 | 69 | 0 | 4 | 1 | 2.45 | .247 | 0.98 | 5.4 | 3.4 | 9.0 | 55.0 | 33 | 15 | 15 | 6 | 21 | 55 | 0 | 8 | 1 | 0 | 0 | 0 | 0 | 3.56 |
| RP | Urbina, U.Urbina, Ugueth >> | 24 | 1998 | R | 59 | 80 | 0 | 3 | 3 | 2.74 | .286 | 1.19 | 6.7 | 4.1 | 9.1 | 62.1 | 46 | 19 | 19 | 4 | 28 | 63 | 0 | 4 | 0 | 0 | 0 | 1 | 2 | 3.21 |
| RP | Marte, D.Marte, Damaso >> | 28 | 2003 | L | 35 | 48 | 0 | 5 | 4 | 2.96 | .286 | 1.18 | 6.2 | 4.6 | 6.2 | 45.2 | 31 | 16 | 15 | 3 | 23 | 31 | 0 | 3 | 2 | 0 | 0 | 1 | 1 | 4.09 |
| RP | Messersmith, A.Messersmith, Andy >> | 23 | 1968 | R | 57 | 34 | 0 | 4 | 2 | 2.61 | .279 | 1.10 | 6.4 | 3.5 | 4.2 | 69.0 | 49 | 20 | 20 | 3 | 27 | 32 | 0 | 1 | 1 | 0 | 0 | 4 | 2 | 3.99 |