| SP | McNally, D.McNally, Dave >> | 26 | 1968 | L | 96 | 34 | 34 | 10 | 19 | 4.63 | .322 | 1.40 | 8.8 | 3.8 | 5.3 | 241.0 | 236 | 133 | 124 | 25 | 101 | 142 | 12 | 0 | 0 | 1 | 13 | 7 | 12 | 4.51 |
| SP | Clemens, R.Clemens, Roger >> | 24 | 1986 | R | 69 | 32 | 32 | 7 | 14 | 5.89 | .345 | 1.55 | 10.8 | 3.2 | 5.3 | 204.2 | 245 | 141 | 134 | 48 | 73 | 121 | 7 | 0 | 0 | 0 | 10 | 5 | 9 | 6.02 |
| SP | Harden, R.Harden, Rich # >> | 27 | 2008 | R | 60 | 31 | 31 | 7 | 13 | 5.62 | .340 | 1.52 | 9.2 | 4.5 | 8.6 | 171.1 | 175 | 119 | 107 | 24 | 86 | 163 | 0 | 0 | 0 | 0 | 9 | 4 | 3 | 4.50 |
| RP | Street, H.Street, Huston # >> | 29 | 2012 | R | 96 | 75 | 0 | 2 | 4 | 4.55 | .299 | 1.27 | 7.3 | 4.2 | 8.0 | 93.0 | 75 | 51 | 47 | 8 | 43 | 83 | 0 | 7 | 5 | 0 | 0 | 1 | 1 | 3.75 |
| RP | Gallegos, G.Gallegos, Giovanny >> | 27 | 2019 | R | 82 | 66 | 0 | 8 | 6 | 4.33 | .283 | 1.18 | 8.0 | 2.6 | 7.9 | 89.1 | 79 | 48 | 43 | 16 | 26 | 78 | 0 | 5 | 2 | 0 | 0 | 1 | 2 | 4.49 |
| RP | Dotel, O.Dotel, Octavio >> | 29 | 2002 | R | 68 | 54 | 0 | 5 | 4 | 5.81 | .356 | 1.66 | 9.6 | 5.4 | 9.0 | 57.1 | 61 | 41 | 37 | 10 | 34 | 57 | 0 | 2 | 2 | 0 | 0 | 0 | 1 | 5.07 |
| RP | Foulke, K.Foulke, Keith >> | 27 | 1999 | R | 59 | 40 | 0 | 2 | 1 | 2.81 | .262 | 1.04 | 7.9 | 1.5 | 10.7 | 48.0 | 42 | 18 | 15 | 10 | 8 | 57 | 0 | 5 | 1 | 0 | 0 | 1 | 1 | 3.90 |
| SP | Carlton, S.Carlton, Steve >> | 28 | 1972 | L | 51 | 3 | 0 | 0 | 1 | 9.00 | .368 | 1.75 | 13.5 | 2.3 | 9.0 | 4.0 | 6 | 4 | 4 | 1 | 1 | 4 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 5.00 |
| SP | Drysdale, D.Drysdale, Don >> | 28 | 1964 | R | 59 | 18 | 0 | 1 | 0 | 6.39 | .397 | 1.93 | 12.6 | 5.0 | 5.4 | 25.1 | 35 | 19 | 18 | 6 | 14 | 15 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 6.72 |