| SP | Tiant, L.Tiant, Luis # >> | 28 | 1968 | R | 97 | 29 | 29 | 15 | 10 | 4.09 | .288 | 1.20 | 7.0 | 3.8 | 7.6 | 204.2 | 158 | 98 | 93 | 19 | 87 | 173 | 10 | 0 | 0 | 2 | 14 | 3 | 3 | 3.84 |
| SP | Adams, B.Adams, Babe # >> | 27 | 1909 | R | 86 | 28 | 28 | 8 | 7 | 4.19 | .320 | 1.37 | 9.3 | 3.0 | 4.4 | 148.1 | 153 | 74 | 69 | 14 | 50 | 72 | 0 | 0 | 0 | 0 | 8 | 6 | 1 | 4.39 |
| SP | Pfiester, J.Pfiester, Jack >> | 28 | 1906 | L | 73 | 28 | 28 | 6 | 18 | 4.81 | .328 | 1.44 | 9.0 | 3.9 | 5.2 | 187.0 | 187 | 111 | 100 | 28 | 82 | 109 | 9 | 0 | 0 | 2 | 12 | 5 | 1 | 5.18 |
| SP | Coveleski, S.Coveleski, Stan >> | 28 | 1917 | R | 62 | 27 | 27 | 7 | 9 | 5.16 | .343 | 1.55 | 9.2 | 4.8 | 4.5 | 151.2 | 154 | 99 | 87 | 20 | 81 | 76 | 1 | 0 | 0 | 0 | 9 | 3 | 2 | 5.38 |
| RP | Jansen, K.Jansen, Kenley >> | 28 | 2016 | R | 97 | 68 | 0 | 2 | 3 | 3.11 | .273 | 1.12 | 7.2 | 2.9 | 9.5 | 101.1 | 81 | 36 | 35 | 10 | 32 | 107 | 0 | 3 | 2 | 0 | 0 | 1 | 3 | 3.15 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 84 | 65 | 0 | 2 | 1 | 4.32 | .302 | 1.28 | 9.5 | 2.0 | 9.0 | 85.1 | 90 | 42 | 41 | 10 | 19 | 85 | 0 | 8 | 8 | 0 | 0 | 2 | 1 | 3.27 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 71 | 57 | 0 | 5 | 4 | 4.23 | .322 | 1.39 | 6.7 | 5.9 | 8.6 | 66.0 | 49 | 36 | 31 | 10 | 43 | 63 | 0 | 4 | 5 | 0 | 0 | 2 | 4 | 5.11 |
| RP | Broxton, J.Broxton, Jonathan >> | 25 | 2009 | R | 62 | 52 | 0 | 6 | 3 | 3.69 | .282 | 1.16 | 6.9 | 3.5 | 7.8 | 61.0 | 47 | 26 | 25 | 8 | 24 | 53 | 0 | 3 | 1 | 0 | 0 | 1 | 4 | 4.20 |
| RP | Wuertz, M.Wuertz, Michael >> | 31 | 2009 | R | 55 | 41 | 0 | 1 | 2 | 3.96 | .321 | 1.38 | 8.8 | 3.6 | 9.0 | 50.0 | 49 | 22 | 22 | 5 | 20 | 50 | 0 | 4 | 1 | 0 | 0 | 2 | 4 | 3.62 |