| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 34 | 34 | 11 | 16 | 3.71 | .278 | 1.12 | 7.7 | 2.4 | 9.0 | 221.0 | 188 | 94 | 91 | 27 | 59 | 221 | 2 | 0 | 0 | 0 | 23 | 8 | 0 | 3.50 |
| SP | Fernandez, J.Fernandez, Jose >> | 21 | 2013 | R | 76 | 31 | 31 | 12 | 11 | 6.46 | .358 | 1.65 | 10.5 | 4.3 | 8.5 | 164.1 | 192 | 120 | 118 | 27 | 79 | 155 | 0 | 0 | 0 | 0 | 11 | 4 | 2 | 4.77 |
| CL | Uehara, K.Uehara, Koji † >> | 38 | 2013 | R | 100 | 48 | 0 | 1 | 3 | 3.48 | .279 | 1.14 | 8.3 | 2.0 | 11.0 | 41.1 | 38 | 17 | 16 | 5 | 9 | 50 | 0 | 35 | 6 | 0 | 0 | 1 | 0 | 2.88 |
| SU | Miller, A.Miller, Andrew >> | 29 | 2014 | L | 88 | 59 | 0 | 3 | 1 | 2.27 | .241 | 0.92 | 6.0 | 2.3 | 9.7 | 67.1 | 45 | 19 | 17 | 8 | 17 | 72 | 0 | 1 | 2 | 0 | 0 | 2 | 1 | 3.25 |
| RP | Benoit, J.Benoit, Joaquin >> | 33 | 2010 | R | 95 | 72 | 0 | 3 | 6 | 4.96 | .333 | 1.49 | 9.0 | 4.4 | 8.5 | 85.1 | 85 | 53 | 47 | 13 | 42 | 80 | 0 | 0 | 3 | 0 | 0 | 1 | 0 | 4.62 |
| RP | Devine, J.Devine, Joey >> | 25 | 2008 | R | 80 | 31 | 0 | 2 | 0 | 2.62 | .318 | 1.40 | 8.2 | 4.5 | 9.3 | 34.1 | 31 | 10 | 10 | 3 | 17 | 35 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 3.59 |
| RP | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 75 | 19 | 0 | 2 | 1 | 3.60 | .342 | 1.52 | 6.5 | 7.2 | 9.4 | 25.0 | 18 | 10 | 10 | 4 | 20 | 26 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 5.52 |
| RP | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 67 | 32 | 0 | 3 | 0 | 3.86 | .263 | 1.07 | 6.1 | 3.6 | 7.1 | 37.1 | 25 | 16 | 16 | 4 | 15 | 29 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 4.05 |