| SP | Clemens, R.Clemens, Roger >> | 43 | 2005 | R | 94 | 10 | 10 | 3 | 4 | 2.82 | .254 | 0.98 | 5.9 | 3.0 | 4.3 | 73.1 | 48 | 25 | 23 | 8 | 24 | 35 | 1 | 0 | 0 | 1 | 10 | 3 | 0 | 4.58 |
| SP | Halladay, R.Halladay, Roy # >> | 28 | 2005 | R | 87 | 9 | 9 | 4 | 4 | 4.00 | .300 | 1.21 | 9.1 | 1.7 | 6.0 | 63.0 | 64 | 31 | 28 | 8 | 12 | 42 | 2 | 0 | 0 | 2 | 5 | 5 | 1 | 4.13 |
| SP | Alvarez, W.Alvarez, Wilson >> | 33 | 2003 | L | 74 | 9 | 9 | 0 | 3 | 4.03 | .325 | 1.39 | 9.2 | 3.3 | 7.8 | 38.0 | 39 | 20 | 17 | 6 | 14 | 33 | 0 | 0 | 0 | 0 | 0 | 2 | 0 | 4.58 |
| SP | Willis, D.Willis, Dontrelle >> | 23 | 2005 | L | 50 | 9 | 9 | 2 | 4 | 4.18 | .322 | 1.41 | 9.8 | 3.0 | 6.0 | 60.1 | 65 | 29 | 28 | 5 | 20 | 40 | 1 | 0 | 0 | 0 | 4 | 1 | 0 | 3.80 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 26 | 2006 | R | 93 | 25 | 0 | 4 | 2 | 3.38 | .283 | 1.18 | 9.5 | 1.3 | 7.4 | 34.2 | 36 | 13 | 13 | 6 | 5 | 28 | 0 | 3 | 1 | 0 | 0 | 0 | 0 | 4.09 |
| RP | Street, H.Street, Huston >> | 24 | 2007 | R | 69 | 21 | 0 | 4 | 1 | 1.29 | .263 | 1.07 | 6.8 | 2.9 | 10.3 | 28.0 | 21 | 4 | 4 | 3 | 9 | 32 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 3.07 |
| RP | Vizcaino, L.Vizcaino, Luis >> | 28 | 2002 | R | 48 | 21 | 0 | 1 | 1 | 4.66 | .356 | 1.66 | 9.9 | 5.2 | 10.4 | 19.1 | 21 | 10 | 10 | 4 | 11 | 22 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 5.16 |
| RP | Zumaya, J.Zumaya, Joel >> | 22 | 2006 | R | 34 | 15 | 0 | 0 | 1 | 4.91 | .368 | 1.69 | 7.5 | 8.0 | 10.0 | 18.1 | 15 | 10 | 10 | 1 | 16 | 20 | 0 | 2 | 2 | 0 | 0 | 1 | 0 | 4.33 |
| RP | Seanez, R.Seanez, Rudy >> | 37 | 2005 | R | 23 | 12 | 0 | 1 | 1 | 3.77 | .338 | 1.53 | 9.6 | 4.5 | 7.1 | 14.1 | 15 | 6 | 6 | 2 | 7 | 11 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 4.79 |
| SP | Person, R.Person, Robert >> | 32 | 2001 | R | 24 | 1 | 0 | 0 | 0 | 0.00 | .375 | 1.80 | 9.0 | 18.0 | 0.0 | 1.2 | 1 | 0 | 0 | 0 | 2 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 9.00 |
| SP | Jimenez, U.Jimenez, Ubaldo | 25 | 2009 | R | 35 | 4 | 0 | 1 | 0 | 15.75 | .478 | 2.75 | 18.0 | 6.8 | 9.0 | 8.0 | 16 | 14 | 14 | 6 | 6 | 8 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 13.00 |