| SP | Clemens, R.Clemens, Roger >> | 43 | 2005 | R | 94 | 26 | 26 | 4 | 13 | 5.66 | .337 | 1.51 | 10.3 | 3.3 | 7.6 | 151.0 | 172 | 98 | 95 | 28 | 56 | 128 | 0 | 0 | 0 | 0 | 12 | 2 | 7 | 4.87 |
| SP | Weaver, J.Weaver, Jered # >> | 24 | 2006 | R | 83 | 25 | 25 | 5 | 10 | 5.16 | .329 | 1.42 | 9.7 | 3.0 | 8.0 | 148.1 | 160 | 88 | 85 | 26 | 50 | 132 | 0 | 0 | 0 | 0 | 13 | 8 | 1 | 4.68 |
| SP | Zambrano, C.Zambrano, Carlos >> | 24 | 2005 | R | 70 | 25 | 25 | 7 | 11 | 5.70 | .337 | 1.53 | 9.6 | 4.2 | 7.4 | 142.0 | 151 | 93 | 90 | 25 | 66 | 117 | 0 | 0 | 0 | 0 | 11 | 0 | 3 | 5.04 |
| SP | Shields, J.Shields, James # >> | 26 | 2007 | R | 53 | 25 | 25 | 9 | 15 | 6.06 | .334 | 1.48 | 11.1 | 2.3 | 6.1 | 156.0 | 192 | 107 | 105 | 36 | 39 | 106 | 1 | 0 | 0 | 0 | 8 | 4 | 7 | 5.47 |
| SP | Willis, D.Willis, Dontrelle >> | 23 | 2005 | L | 50 | 24 | 24 | 8 | 11 | 5.41 | .351 | 1.57 | 10.4 | 3.8 | 6.5 | 141.1 | 163 | 93 | 85 | 24 | 59 | 102 | 0 | 0 | 0 | 0 | 11 | 7 | 3 | 5.17 |
| RP | Jenks, B.Jenks, Bobby † >> | 26 | 2007 | R | 70 | 69 | 0 | 7 | 2 | 3.31 | .295 | 1.21 | 8.0 | 2.9 | 6.4 | 84.1 | 75 | 33 | 31 | 3 | 27 | 60 | 0 | 8 | 1 | 0 | 0 | 4 | 6 | 3.14 |
| RP | Vizcaino, L.Vizcaino, Luis >> | 28 | 2002 | R | 48 | 54 | 0 | 3 | 2 | 3.44 | .313 | 1.33 | 8.3 | 3.6 | 8.0 | 55.0 | 51 | 24 | 21 | 6 | 22 | 49 | 0 | 7 | 0 | 0 | 0 | 2 | 2 | 3.95 |
| RP | Howell, J.Howell, J.P. >> | 25 | 2008 | L | 35 | 48 | 0 | 1 | 3 | 5.72 | .382 | 1.78 | 11.4 | 4.8 | 7.6 | 56.2 | 71 | 37 | 36 | 7 | 30 | 47 | 0 | 2 | 4 | 0 | 0 | 4 | 0 | 4.77 |
| RP | Seanez, R.Seanez, Rudy >> | 37 | 2005 | R | 23 | 44 | 0 | 3 | 2 | 5.55 | .344 | 1.55 | 10.9 | 3.1 | 11.1 | 47.0 | 57 | 30 | 29 | 8 | 16 | 58 | 0 | 5 | 0 | 0 | 0 | 1 | 5 | 3.83 |
| SP | Matsuzaka, D.Matsuzaka, Daisuke >> | 28 | 2008 | R | 33 | 1 | 0 | 0 | 0 | 7.71 | .300 | 1.29 | 9.0 | 4.5 | 4.5 | 2.1 | 2 | 2 | 2 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 10.00 |
| SP | Arroyo, B.Arroyo, Bronson >> | 29 | 2006 | R | 21 | 14 | 0 | 0 | 2 | 6.08 | .343 | 1.48 | 8.6 | 5.1 | 4.3 | 23.2 | 22 | 16 | 16 | 4 | 13 | 11 | 0 | 3 | 1 | 0 | 0 | 2 | 0 | 6.26 |