| SP | Johnson, R.Johnson, Randy # >> | 38 | 2001 | L | 97 | 12 | 12 | 5 | 3 | 4.04 | .282 | 1.13 | 7.5 | 2.8 | 11.5 | 84.2 | 70 | 39 | 38 | 11 | 26 | 107 | 2 | 0 | 0 | 1 | 6 | 4 | 3 | 3.23 |
| SP | Buehrle, M.Buehrle, Mark >> | 22 | 2001 | L | 66 | 12 | 11 | 5 | 5 | 6.79 | .355 | 1.62 | 10.5 | 4.2 | 7.0 | 62.1 | 72 | 47 | 47 | 9 | 29 | 48 | 0 | 0 | 0 | 0 | 5 | 2 | 3 | 4.84 |
| SP | Shields, J.Shields, James >> | 26 | 2007 | R | 52 | 11 | 11 | 3 | 4 | 8.48 | .398 | 1.90 | 13.7 | 3.5 | 8.3 | 52.0 | 79 | 49 | 49 | 14 | 20 | 48 | 0 | 0 | 0 | 0 | 2 | 4 | 2 | 6.04 |
| SP | Kazmir, S.Kazmir, Scott >> | 24 | 2008 | L | 40 | 12 | 11 | 2 | 3 | 4.43 | .356 | 1.66 | 9.7 | 5.2 | 8.1 | 61.0 | 66 | 30 | 30 | 8 | 35 | 55 | 0 | 0 | 0 | 0 | 4 | 0 | 1 | 4.62 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 96 | 32 | 0 | 1 | 6 | 3.94 | .267 | 1.01 | 7.8 | 1.4 | 9.2 | 45.2 | 39 | 21 | 20 | 6 | 7 | 46 | 0 | 0 | 4 | 0 | 0 | 4 | 2 | 3.42 |
| RP | Rhodes, A.Rhodes, Arthur >> | 32 | 2001 | L | 83 | 36 | 0 | 2 | 0 | 5.05 | .317 | 1.37 | 9.2 | 3.4 | 7.9 | 51.2 | 52 | 29 | 29 | 4 | 19 | 45 | 0 | 1 | 1 | 0 | 0 | 1 | 5 | 3.43 |
| RP | Street, H.Street, Huston >> | 24 | 2007 | R | 68 | 30 | 0 | 2 | 2 | 4.76 | .320 | 1.39 | 8.1 | 4.6 | 9.0 | 39.2 | 35 | 23 | 21 | 5 | 20 | 39 | 0 | 3 | 3 | 0 | 0 | 1 | 0 | 4.28 |
| RP | Williamson, S.Williamson, Scott >> | 26 | 2002 | R | 51 | 26 | 0 | 0 | 3 | 5.25 | .379 | 1.75 | 10.1 | 5.6 | 11.3 | 24.0 | 27 | 16 | 14 | 2 | 15 | 30 | 0 | 4 | 1 | 0 | 0 | 2 | 0 | 3.71 |
| RP | Hawkins, L.Hawkins, LaTroy >> | 30 | 2002 | R | 40 | 17 | 0 | 1 | 0 | 4.15 | .244 | 0.92 | 5.6 | 3.0 | 8.1 | 21.2 | 13 | 10 | 10 | 3 | 7 | 19 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 4.19 |