| SP | Hernandez, F.Hernandez, Felix >> | 19 | 2005 | R | 96 | 26 | 26 | 8 | 7 | 3.74 | .299 | 1.22 | 7.9 | 3.2 | 7.7 | 190.1 | 166 | 81 | 79 | 19 | 67 | 162 | 2 | 0 | 0 | 1 | 14 | 10 | 4 | 3.81 |
| SP | Perez, O.Perez, Oliver # >> | 23 | 2004 | L | 76 | 25 | 25 | 9 | 8 | 4.37 | .317 | 1.35 | 8.9 | 3.3 | 9.8 | 152.1 | 151 | 83 | 74 | 19 | 55 | 166 | 2 | 0 | 0 | 1 | 14 | 6 | 1 | 3.64 |
| SP | Santana, E.Santana, Ervin >> | 25 | 2008 | R | 55 | 25 | 25 | 7 | 11 | 6.13 | .350 | 1.57 | 11.0 | 3.2 | 6.7 | 142.1 | 174 | 105 | 97 | 30 | 50 | 106 | 0 | 0 | 0 | 0 | 9 | 6 | 3 | 5.44 |
| RP | Rivera, M.Rivera, Mariano † >> | 39 | 2008 | R | 96 | 68 | 0 | 8 | 4 | 3.06 | .237 | 0.92 | 6.7 | 1.6 | 9.4 | 100.0 | 74 | 34 | 34 | 16 | 18 | 104 | 0 | 7 | 3 | 0 | 0 | 1 | 0 | 3.57 |
| RP | Zimmerman, J.Zimmerman, Jeff † >> | 29 | 2001 | R | 76 | 63 | 0 | 5 | 3 | 2.22 | .256 | 0.99 | 6.1 | 2.8 | 8.4 | 89.1 | 60 | 24 | 22 | 10 | 28 | 83 | 0 | 7 | 2 | 0 | 0 | 4 | 0 | 3.67 |
| RP | Takatsu, S.Takatsu, Shingo # >> | 36 | 2004 | R | 57 | 50 | 0 | 3 | 4 | 5.07 | .329 | 1.42 | 8.3 | 4.4 | 6.9 | 55.0 | 51 | 32 | 31 | 10 | 27 | 42 | 0 | 4 | 1 | 0 | 0 | 3 | 0 | 5.47 |
| RP | Fuentes, B.Fuentes, Brian >> | 33 | 2008 | L | 33 | 33 | 0 | 3 | 3 | 6.39 | .329 | 1.45 | 9.7 | 3.3 | 10.9 | 38.0 | 41 | 27 | 27 | 3 | 14 | 46 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 2.79 |
| SP | Verlander, J.Verlander, Justin >> | 26 | 2009 | R | 42 | 0 | 0 | 0 | 0 | - | .000 | - | - | - | - | 0.0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | - |
| SP | Washburn, J.Washburn, Jarrod >> | 28 | 2002 | L | 32 | 14 | 0 | 2 | 1 | 7.58 | .400 | 2.00 | 14.2 | 3.8 | 6.2 | 19.0 | 30 | 16 | 16 | 2 | 8 | 13 | 0 | 4 | 1 | 0 | 0 | 0 | 0 | 4.26 |