| SP | Schilling, C.Schilling, Curt >> | 36 | 2002 | R | 93 | 10 | 10 | 2 | 3 | 5.06 | .336 | 1.45 | 11.0 | 2.2 | 9.5 | 58.2 | 71 | 35 | 33 | 11 | 14 | 61 | 0 | 0 | 0 | 0 | 6 | 4 | 2 | 4.29 |
| SP | Pettitte, A.Pettitte, Andy >> | 33 | 2005 | L | 78 | 6 | 3 | 0 | 0 | 7.41 | .346 | 1.53 | 8.5 | 5.3 | 5.8 | 17.0 | 16 | 14 | 14 | 2 | 10 | 11 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 5.18 |
| SP | Zambrano, C.Zambrano, Carlos >> | 24 | 2005 | R | 70 | 9 | 9 | 1 | 5 | 6.49 | .397 | 1.86 | 11.7 | 5.0 | 7.3 | 43.0 | 56 | 33 | 31 | 7 | 24 | 35 | 0 | 0 | 0 | 0 | 1 | 5 | 3 | 5.51 |
| SP | Maddux, G.Maddux, Greg >> | 34 | 2000 | R | 58 | 2 | 2 | 0 | 0 | 10.24 | .463 | 2.48 | 18.0 | 6.0 | 7.0 | 9.2 | 18 | 11 | 11 | 3 | 6 | 7 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 8.11 |
| RP | Benitez, A.Benitez, Armando >> | 32 | 2004 | R | 91 | 21 | 0 | 1 | 3 | 6.46 | .366 | 1.69 | 10.2 | 5.5 | 5.5 | 23.2 | 26 | 18 | 17 | 6 | 14 | 14 | 0 | 3 | 2 | 0 | 0 | 1 | 0 | 7.13 |
| RP | Guardado, E.Guardado, Eddie >> | 34 | 2004 | L | 56 | 6 | 0 | 0 | 2 | 9.00 | .455 | 2.50 | 18.0 | 4.5 | 11.3 | 4.0 | 8 | 6 | 4 | 3 | 2 | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 11.75 |
| SU | Wuertz, M.Wuertz, Michael >> | 31 | 2009 | R | 73 | 21 | 0 | 1 | 0 | 4.95 | .277 | 1.15 | 6.3 | 4.1 | 9.5 | 20.0 | 14 | 12 | 11 | 1 | 9 | 21 | 0 | 2 | 1 | 0 | 0 | 0 | 1 | 2.90 |
| SP | Young, C.Young, Chris # >> | 28 | 2007 | R | 82 | 8 | 7 | 1 | 4 | 8.41 | .376 | 1.73 | 12.3 | 3.3 | 8.2 | 35.1 | 48 | 36 | 33 | 6 | 13 | 32 | 0 | 0 | 0 | 0 | 1 | 3 | 2 | 4.77 |
| CL | Rodriguez, F.Rodriguez, Francisco >> | 22 | 2004 | R | 70 | 24 | 0 | 2 | 1 | 2.97 | .311 | 1.35 | 8.4 | 3.9 | 11.1 | 30.1 | 28 | 10 | 10 | 3 | 13 | 37 | 0 | 2 | 0 | 0 | 0 | 0 | 2 | 3.13 |