| SP | Hernandez, F.Hernandez, Felix >> | 19 | 2005 | R | 96 | 10 | 10 | 5 | 3 | 4.20 | .316 | 1.37 | 9.4 | 3.0 | 5.1 | 64.1 | 67 | 31 | 30 | 9 | 21 | 36 | 0 | 0 | 0 | 0 | 6 | 1 | 3 | 4.73 |
| SP | Bedard, E.Bedard, Erik >> | 28 | 2007 | L | 80 | 9 | 9 | 1 | 4 | 6.84 | .375 | 1.76 | 12.6 | 3.2 | 9.9 | 50.0 | 70 | 42 | 38 | 11 | 18 | 55 | 0 | 0 | 0 | 0 | 3 | 2 | 1 | 4.86 |
| SP | Hamels, C.Hamels, Cole >> | 25 | 2008 | L | 72 | 9 | 9 | 3 | 4 | 3.77 | .323 | 1.43 | 9.0 | 3.9 | 7.3 | 57.1 | 57 | 27 | 24 | 7 | 25 | 46 | 0 | 0 | 0 | 0 | 6 | 0 | 0 | 4.30 |
| SP | Buehrle, M.Buehrle, Mark >> | 22 | 2001 | L | 67 | 9 | 9 | 6 | 1 | 3.96 | .296 | 1.24 | 9.0 | 2.3 | 6.2 | 52.1 | 52 | 24 | 23 | 13 | 13 | 36 | 0 | 0 | 0 | 0 | 5 | 1 | 2 | 5.67 |
| SP | Shields, J.Shields, James # >> | 26 | 2007 | R | 53 | 9 | 9 | 2 | 5 | 5.86 | .339 | 1.44 | 10.8 | 2.3 | 6.3 | 50.2 | 60 | 36 | 33 | 7 | 13 | 35 | 1 | 0 | 0 | 1 | 4 | 5 | 1 | 4.50 |
| CL | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 97 | 15 | 0 | 1 | 4 | 4.08 | .243 | 0.96 | 6.4 | 2.6 | 7.9 | 17.2 | 12 | 8 | 8 | 3 | 5 | 15 | 0 | 7 | 3 | 0 | 0 | 0 | 0 | 4.41 |
| RP | Hoffman, T.Hoffman, Trevor >> | 42 | 2009 | R | 72 | 20 | 0 | 1 | 1 | 3.79 | .360 | 1.68 | 12.3 | 2.8 | 9.5 | 19.0 | 26 | 11 | 8 | 2 | 6 | 20 | 0 | 0 | 1 | 0 | 0 | 0 | 3 | 3.21 |
| RP | Cormier, R.Cormier, Rheal >> | 36 | 2003 | L | 63 | 14 | 0 | 1 | 1 | 3.94 | .273 | 1.13 | 6.2 | 3.9 | 2.8 | 16.0 | 11 | 8 | 7 | 4 | 7 | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 6.94 |
| RP | Okajima, H.Okajima, Hideki >> | 32 | 2007 | L | 53 | 12 | 0 | 0 | 0 | 6.75 | .345 | 1.58 | 12.0 | 2.3 | 9.8 | 12.0 | 16 | 9 | 9 | 1 | 3 | 13 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.67 |
| SU | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 87 | 17 | 0 | 0 | 0 | 4.03 | .309 | 1.30 | 9.8 | 2.0 | 9.8 | 22.1 | 24 | 10 | 10 | 2 | 5 | 24 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 2.82 |