| SP | Martinez, P.Martinez, Pedro † >> | 29 | 2000 | R | 100 | 24 | 24 | 13 | 8 | 3.32 | .263 | 1.06 | 6.9 | 2.6 | 10.0 | 181.2 | 139 | 70 | 67 | 25 | 53 | 202 | 8 | 0 | 0 | 3 | 15 | 2 | 2 | 3.48 |
| SP | Peavy, J.Peavy, Jake # >> | 26 | 2007 | R | 89 | 26 | 26 | 11 | 3 | 3.68 | .292 | 1.19 | 8.3 | 2.5 | 8.4 | 181.0 | 166 | 78 | 74 | 20 | 50 | 169 | 4 | 0 | 0 | 1 | 16 | 8 | 1 | 3.53 |
| SP | Carpenter, C.Carpenter, Chris >> | 34 | 2009 | R | 80 | 25 | 25 | 10 | 9 | 4.76 | .310 | 1.32 | 9.8 | 2.1 | 7.0 | 155.0 | 168 | 88 | 82 | 25 | 36 | 120 | 3 | 0 | 0 | 1 | 13 | 5 | 5 | 4.34 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 86 | 61 | 0 | 5 | 5 | 5.17 | .354 | 1.63 | 8.1 | 6.7 | 10.2 | 62.2 | 56 | 44 | 36 | 10 | 46 | 70 | 0 | 2 | 3 | 0 | 0 | 1 | 1 | 5.11 |
| RP | Foulke, K.Foulke, Keith >> | 31 | 2003 | R | 78 | 50 | 0 | 4 | 3 | 4.74 | .286 | 1.19 | 8.7 | 2.0 | 8.7 | 68.1 | 66 | 40 | 36 | 16 | 15 | 66 | 0 | 1 | 4 | 0 | 0 | 1 | 0 | 4.82 |
| RP | Street, H.Street, Huston >> | 24 | 2007 | R | 69 | 40 | 0 | 1 | 2 | 3.80 | .286 | 1.18 | 8.0 | 2.6 | 10.4 | 45.0 | 40 | 19 | 19 | 8 | 13 | 52 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 3.93 |
| RP | Rincon, J.Rincon, Juan >> | 25 | 2004 | R | 61 | 40 | 0 | 5 | 3 | 3.51 | .308 | 1.29 | 8.3 | 3.6 | 11.3 | 48.2 | 44 | 19 | 19 | 7 | 19 | 60 | 0 | 0 | 3 | 0 | 0 | 2 | 0 | 3.71 |
| SU | Wagner, B.Wagner, Billy >> | 32 | 2003 | L | 90 | 46 | 0 | 2 | 1 | 2.42 | .296 | 1.26 | 6.9 | 4.5 | 9.0 | 48.1 | 37 | 14 | 13 | 6 | 24 | 48 | 0 | 4 | 2 | 0 | 0 | 0 | 3 | 4.13 |