| SP | Koufax, S.Koufax, Sandy >> | 30 | 1965 | L | 98 | 27 | 27 | 9 | 14 | 4.31 | .287 | 1.18 | 8.0 | 2.6 | 8.8 | 188.0 | 167 | 95 | 90 | 31 | 55 | 184 | 5 | 0 | 0 | 0 | 13 | 5 | 6 | 4.14 |
| SP | Johnson, W.Johnson, Walter >> | 26 | 1913 | R | 95 | 28 | 28 | 13 | 7 | 4.24 | .319 | 1.38 | 10.1 | 2.3 | 5.2 | 191.0 | 215 | 97 | 90 | 22 | 49 | 110 | 4 | 0 | 0 | 0 | 14 | 4 | 2 | 4.18 |
| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 93 | 29 | 29 | 8 | 15 | 4.76 | .323 | 1.42 | 9.8 | 3.0 | 7.9 | 189.0 | 205 | 107 | 100 | 21 | 63 | 165 | 2 | 0 | 0 | 0 | 14 | 3 | 4 | 3.75 |
| SP | Maddux, G.Maddux, Greg >> | 29 | 1995 | R | 89 | 28 | 28 | 8 | 14 | 5.92 | .328 | 1.45 | 11.0 | 2.1 | 5.6 | 165.2 | 202 | 112 | 109 | 31 | 38 | 103 | 3 | 0 | 0 | 2 | 12 | 3 | 3 | 4.94 |
| SU | Boxberger, B.Boxberger, Brad >> | 26 | 2014 | R | 83 | 63 | 0 | 2 | 3 | 4.45 | .274 | 1.10 | 6.0 | 4.1 | 8.0 | 62.2 | 41 | 31 | 31 | 6 | 28 | 55 | 0 | 0 | 4 | 0 | 0 | 2 | 2 | 3.94 |
| RP | Harvey, B.Harvey, Bryan >> | 28 | 1991 | R | 66 | 67 | 0 | 4 | 1 | 4.44 | .299 | 1.23 | 8.1 | 3.0 | 8.7 | 79.0 | 71 | 41 | 39 | 8 | 26 | 76 | 0 | 3 | 0 | 0 | 0 | 4 | 0 | 3.53 |
| RP | Bailey, A.Bailey, Andrew >> | 25 | 2009 | R | 66 | 46 | 0 | 0 | 1 | 5.24 | .343 | 1.52 | 9.4 | 4.5 | 8.4 | 44.2 | 46 | 26 | 26 | 11 | 22 | 41 | 0 | 2 | 1 | 0 | 0 | 2 | 3 | 6.02 |