| SP | Koufax, S.Koufax, Sandy † >> | 30 | 1965 | L | 97 | 20 | 20 | 10 | 9 | 3.32 | .306 | 1.31 | 9.3 | 2.6 | 8.2 | 154.2 | 159 | 60 | 57 | 17 | 44 | 141 | 4 | 0 | 0 | 0 | 14 | 2 | 3 | 3.50 |
| SP | Johnson, W.Johnson, Walter >> | 26 | 1913 | R | 95 | 19 | 19 | 8 | 7 | 3.90 | .288 | 1.20 | 8.6 | 2.3 | 4.7 | 131.2 | 125 | 65 | 57 | 21 | 33 | 69 | 3 | 0 | 0 | 0 | 10 | 2 | 0 | 4.83 |
| SP | Leonard, D.Leonard, Dutch >> | 22 | 1914 | L | 91 | 19 | 19 | 4 | 8 | 4.06 | .301 | 1.26 | 7.5 | 3.8 | 4.3 | 115.1 | 96 | 54 | 52 | 9 | 49 | 55 | 1 | 0 | 0 | 0 | 10 | 4 | 1 | 4.44 |
| SP | Maddux, G.Maddux, Greg >> | 29 | 1995 | R | 89 | 18 | 18 | 6 | 7 | 4.88 | .307 | 1.29 | 9.8 | 1.8 | 5.6 | 107.0 | 117 | 60 | 58 | 17 | 21 | 67 | 0 | 0 | 0 | 0 | 8 | 4 | 5 | 4.51 |
| SP | Alexander, P.Alexander, Pete >> | 28 | 1915 | R | 88 | 19 | 18 | 7 | 9 | 4.94 | .325 | 1.45 | 9.8 | 3.2 | 5.1 | 120.1 | 131 | 72 | 66 | 21 | 43 | 68 | 3 | 0 | 0 | 0 | 8 | 0 | 2 | 5.22 |
| SU | Balfour, G.Balfour, Grant >> | 31 | 2008 | R | 76 | 52 | 0 | 2 | 2 | 3.04 | .273 | 1.09 | 3.9 | 5.9 | 9.0 | 53.1 | 23 | 18 | 18 | 4 | 35 | 53 | 0 | 3 | 1 | 0 | 0 | 2 | 3 | 4.08 |
| RP | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 68 | 39 | 0 | 3 | 2 | 3.86 | .304 | 1.31 | 6.8 | 5.1 | 7.2 | 44.1 | 33 | 20 | 19 | 4 | 25 | 35 | 0 | 1 | 2 | 0 | 0 | 0 | 0 | 4.30 |
| RP | Sutter, B.Sutter, Bruce >> | 24 | 1977 | R | 69 | 30 | 0 | 1 | 0 | 5.45 | .316 | 1.36 | 8.5 | 4.0 | 9.8 | 34.2 | 32 | 21 | 21 | 3 | 15 | 37 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 3.38 |