| SP | Martinez, P.Martinez, Pedro # >> | 29 | 2000 | R | 100 | 23 | 23 | 6 | 13 | 3.57 | .261 | 1.04 | 7.4 | 2.0 | 8.6 | 176.1 | 144 | 77 | 70 | 27 | 39 | 168 | 3 | 0 | 0 | 0 | 14 | 4 | 3 | 3.82 |
| SP | McNally, D.McNally, Dave >> | 26 | 1968 | L | 96 | 22 | 22 | 6 | 13 | 4.20 | .299 | 1.27 | 8.7 | 2.8 | 4.4 | 156.1 | 151 | 78 | 73 | 22 | 48 | 77 | 7 | 0 | 0 | 1 | 12 | 1 | 1 | 4.79 |
| SP | Scherzer, M.Scherzer, Max >> | 33 | 2017 | R | 95 | 22 | 22 | 8 | 6 | 4.22 | .315 | 1.34 | 9.1 | 3.1 | 9.5 | 138.2 | 139 | 67 | 65 | 13 | 47 | 145 | 2 | 0 | 0 | 0 | 14 | 5 | 0 | 3.25 |
| SP | Krause, H.Krause, Harry >> | 21 | 1909 | L | 72 | 22 | 22 | 4 | 10 | 4.76 | .329 | 1.44 | 9.3 | 3.7 | 4.5 | 130.1 | 135 | 73 | 69 | 16 | 53 | 65 | 0 | 0 | 0 | 0 | 12 | 4 | 3 | 4.92 |
| SP | Seaver, T.Seaver, Tom # >> | 27 | 1971 | R | 71 | 22 | 22 | 6 | 11 | 5.88 | .326 | 1.43 | 10.2 | 2.7 | 9.7 | 131.2 | 148 | 91 | 86 | 32 | 40 | 141 | 2 | 0 | 0 | 0 | 8 | 3 | 2 | 5.01 |
| RP | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 99 | 54 | 0 | 4 | 1 | 4.28 | .263 | 1.07 | 7.3 | 2.5 | 9.9 | 73.2 | 59 | 37 | 35 | 16 | 20 | 80 | 0 | 6 | 3 | 0 | 0 | 0 | 2 | 4.48 |
| RP | Street, H.Street, Huston >> | 29 | 2012 | R | 96 | 54 | 0 | 3 | 6 | 3.19 | .321 | 1.38 | 7.5 | 5.0 | 8.2 | 59.1 | 49 | 28 | 21 | 8 | 33 | 54 | 0 | 8 | 5 | 0 | 0 | 2 | 0 | 4.71 |
| RP | Boxberger, B.Boxberger, Brad >> | 26 | 2014 | R | 83 | 28 | 0 | 3 | 1 | 2.51 | .271 | 1.12 | 6.8 | 3.5 | 10.9 | 28.2 | 21 | 10 | 8 | 3 | 11 | 34 | 0 | 2 | 1 | 0 | 0 | 0 | 4 | 3.14 |
| RP | Soria, J.Soria, Joakim >> | 24 | 2008 | R | 68 | 19 | 0 | 1 | 3 | 8.18 | .394 | 1.95 | 11.9 | 5.7 | 6.1 | 22.0 | 29 | 21 | 20 | 6 | 14 | 15 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 7.09 |
| RP | Foulke, K.Foulke, Keith >> | 27 | 1999 | R | 60 | 22 | 0 | 1 | 2 | 2.96 | .219 | 0.84 | 6.7 | 1.0 | 7.7 | 27.1 | 20 | 9 | 9 | 1 | 3 | 23 | 0 | 0 | 0 | 0 | 0 | 0 | 2 | 2.11 |
| SP | Drysdale, D.Drysdale, Don >> | 28 | 1964 | R | 59 | 7 | 0 | 1 | 0 | 7.88 | .429 | 2.25 | 19.1 | 1.1 | 4.5 | 8.0 | 17 | 7 | 7 | 2 | 1 | 4 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 5.63 |