| SP | Kluber, C.Kluber, Corey # >> | 31 | 2017 | R | 89 | 28 | 28 | 12 | 12 | 3.97 | .279 | 1.15 | 7.9 | 2.5 | 8.4 | 197.1 | 172 | 89 | 87 | 31 | 54 | 184 | 2 | 0 | 0 | 0 | 16 | 3 | 2 | 4.05 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 86 | 28 | 28 | 9 | 11 | 4.38 | .295 | 1.22 | 8.3 | 2.8 | 8.1 | 170.2 | 156 | 86 | 83 | 25 | 52 | 153 | 0 | 0 | 0 | 0 | 15 | 6 | 3 | 4.14 |
| SP | Mathewson, C.Mathewson, Christy >> | 28 | 1908 | R | 82 | 28 | 28 | 12 | 5 | 3.24 | .258 | 1.02 | 7.4 | 1.8 | 4.7 | 203.0 | 166 | 76 | 73 | 13 | 41 | 106 | 4 | 0 | 0 | 1 | 18 | 5 | 0 | 3.47 |
| SP | Johnson, R.Johnson, Randy # >> | 41 | 2004 | L | 84 | 26 | 26 | 14 | 8 | 4.44 | .287 | 1.20 | 8.3 | 2.5 | 8.2 | 176.1 | 163 | 91 | 87 | 23 | 48 | 160 | 4 | 0 | 0 | 0 | 11 | 2 | 1 | 3.73 |
| CL | Rivera, M.Rivera, Mariano # >> | 39 | 2008 | R | 85 | 52 | 0 | 2 | 10 | 4.80 | .327 | 1.44 | 10.1 | 3.1 | 7.7 | 50.2 | 56 | 31 | 27 | 7 | 17 | 43 | 0 | 25 | 2 | 0 | 0 | 1 | 0 | 4.18 |
| SU | Percival, T.Percival, Troy >> | 26 | 1995 | R | 82 | 45 | 0 | 2 | 1 | 3.50 | .312 | 1.32 | 7.2 | 4.7 | 8.8 | 46.1 | 37 | 20 | 18 | 4 | 24 | 45 | 0 | 3 | 5 | 0 | 0 | 2 | 0 | 3.87 |
| RP | Treinen, B.Treinen, Blake >> | 30 | 2018 | R | 79 | 64 | 0 | 3 | 4 | 3.87 | .311 | 1.34 | 8.4 | 3.8 | 8.4 | 76.2 | 71 | 33 | 33 | 7 | 32 | 71 | 0 | 0 | 1 | 0 | 0 | 1 | 4 | 3.63 |
| RP | Zimmerman, J.Zimmerman, Jeff >> | 27 | 1999 | R | 70 | 46 | 0 | 3 | 4 | 4.09 | .340 | 1.55 | 8.8 | 5.1 | 4.9 | 55.0 | 54 | 25 | 25 | 3 | 31 | 30 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 4.31 |
| RP | Sutter, B.Sutter, Bruce >> | 24 | 1977 | R | 67 | 40 | 0 | 2 | 0 | 4.84 | .325 | 1.44 | 10.5 | 2.6 | 6.9 | 35.1 | 41 | 21 | 19 | 9 | 10 | 27 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 5.66 |
| RP | Fingers, R.Fingers, Rollie >> | 35 | 1981 | R | 53 | 10 | 0 | 0 | 1 | 5.56 | .346 | 1.50 | 11.5 | 2.5 | 5.7 | 11.1 | 14 | 7 | 7 | 3 | 3 | 7 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 6.36 |
| SP | Drysdale, D.Drysdale, Don >> | 28 | 1964 | R | 59 | 6 | 0 | 0 | 0 | 4.22 | .281 | 1.13 | 5.6 | 4.7 | 4.7 | 21.1 | 13 | 10 | 10 | 3 | 11 | 11 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 5.52 |