| SP | Alexander, P.Alexander, Pete † >> | 28 | 1915 | R | 88 | 29 | 29 | 19 | 4 | 2.02 | .231 | 0.89 | 5.9 | 2.1 | 4.5 | 231.2 | 152 | 52 | 52 | 10 | 55 | 115 | 9 | 0 | 0 | 3 | 25 | 2 | 2 | 3.31 |
| SP | Coveleski, S.Coveleski, Stan >> | 28 | 1917 | R | 62 | 20 | 15 | 9 | 4 | 3.12 | .287 | 1.18 | 6.5 | 4.1 | 3.0 | 121.0 | 88 | 46 | 42 | 11 | 55 | 40 | 0 | 0 | 0 | 0 | 11 | 3 | 3 | 4.96 |
| SP | McDowell, S.McDowell, Sam >> | 23 | 1965 | L | 44 | 26 | 26 | 16 | 7 | 3.38 | .287 | 1.19 | 7.0 | 3.7 | 7.3 | 178.1 | 139 | 69 | 67 | 13 | 74 | 144 | 2 | 0 | 0 | 1 | 16 | 2 | 6 | 3.61 |
| SP | Pfiester, J.Pfiester, Jack >> | 28 | 1906 | L | 73 | 24 | 23 | 14 | 7 | 3.55 | .315 | 1.36 | 8.5 | 3.7 | 5.1 | 169.2 | 160 | 71 | 67 | 12 | 70 | 95 | 5 | 0 | 0 | 0 | 15 | 4 | 3 | 4.11 |
| CL | Doolittle, S.Doolittle, Sean † >> | 31 | 2018 | L | 99 | 57 | 0 | 8 | 2 | 1.89 | .205 | 0.77 | 6.4 | 0.6 | 7.8 | 62.0 | 44 | 14 | 13 | 4 | 4 | 54 | 0 | 39 | 4 | 0 | 0 | 0 | 1 | 2.29 |
| SU | Holland, G.Holland, Greg >> | 27 | 2013 | R | 71 | 42 | 0 | 1 | 0 | 2.03 | .236 | 0.92 | 4.3 | 4.1 | 10.6 | 44.1 | 21 | 10 | 10 | 2 | 20 | 52 | 0 | 5 | 2 | 0 | 0 | 0 | 1 | 2.59 |
| RP | Drabowsky, M.Drabowsky, Moe >> | 31 | 1966 | R | 53 | 58 | 0 | 4 | 1 | 4.54 | .306 | 1.29 | 6.7 | 5.0 | 7.4 | 67.1 | 50 | 34 | 34 | 6 | 37 | 55 | 0 | 2 | 1 | 0 | 0 | 2 | 0 | 4.27 |
| RP | LaRoche, D.LaRoche, Dave >> | 28 | 1976 | L | 31 | 25 | 0 | 4 | 2 | 2.51 | .333 | 1.40 | 7.4 | 5.5 | 7.7 | 28.2 | 23 | 10 | 8 | 2 | 17 | 24 | 0 | 0 | 3 | 0 | 0 | 3 | 0 | 4.36 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 78 | 17 | 0 | 1 | 1 | 2.05 | .250 | 1.00 | 4.9 | 4.1 | 7.0 | 22.0 | 12 | 5 | 5 | 1 | 10 | 17 | 0 | 0 | 0 | 0 | 0 | 0 | 3 | 3.41 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 63 | 8 | 0 | 1 | 2 | 5.14 | .323 | 1.29 | 6.4 | 5.1 | 9.0 | 7.0 | 5 | 5 | 4 | 1 | 4 | 7 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 5.00 |
| RP | Smoltz, J.Smoltz, John >> | 36 | 2003 | R | 51 | 15 | 0 | 0 | 0 | 2.16 | .306 | 1.26 | 7.3 | 4.5 | 10.7 | 16.2 | 13 | 4 | 4 | 2 | 8 | 19 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 3.94 |
| RP | Capps, C.Capps, Carter >> | 24 | 2015 | R | 84 | 18 | 0 | 0 | 0 | 8.82 | .395 | 1.90 | 14.6 | 2.8 | 9.6 | 16.1 | 26 | 16 | 16 | 2 | 5 | 17 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 3.63 |
| SP | Newhouser, H.Newhouser, Hal >> | 25 | 1946 | L | 30 | 7 | 0 | 0 | 0 | 5.13 | .288 | 1.18 | 7.3 | 3.5 | 7.6 | 26.1 | 21 | 15 | 15 | 5 | 10 | 22 | 0 | 0 | 0 | 0 | 0 | 1 | 2 | 5.08 |