| SP | Richard, J.Richard, J.R. † >> | 30 | 1980 | R | 90 | 29 | 29 | 13 | 7 | 2.99 | .294 | 1.22 | 7.1 | 4.0 | 6.6 | 180.1 | 141 | 64 | 60 | 11 | 79 | 131 | 2 | 0 | 0 | 2 | 14 | 5 | 2 | 3.74 |
| SP | Brown, M.Brown, Mordecai >> | 32 | 1908 | R | 85 | 28 | 28 | 10 | 11 | 3.86 | .277 | 1.12 | 7.7 | 2.3 | 4.2 | 193.1 | 166 | 90 | 83 | 13 | 50 | 89 | 8 | 0 | 0 | 1 | 16 | 6 | 3 | 3.82 |
| SP | Fernandez, J.Fernandez, Jose # >> | 21 | 2013 | R | 76 | 28 | 27 | 8 | 11 | 4.55 | .305 | 1.29 | 7.8 | 3.8 | 7.6 | 156.1 | 135 | 82 | 79 | 16 | 66 | 131 | 1 | 0 | 0 | 0 | 12 | 5 | 3 | 4.02 |
| SP | Waddell, R.Waddell, Rube >> | 29 | 1905 | L | 67 | 27 | 26 | 8 | 8 | 4.26 | .298 | 1.25 | 8.2 | 3.0 | 5.8 | 167.0 | 152 | 81 | 79 | 19 | 56 | 108 | 6 | 0 | 0 | 1 | 16 | 5 | 3 | 4.28 |
| RP | Benitez, A.Benitez, Armando >> | 32 | 2004 | R | 81 | 77 | 0 | 5 | 4 | 3.25 | .302 | 1.28 | 7.5 | 4.0 | 6.3 | 105.1 | 88 | 40 | 38 | 14 | 47 | 73 | 0 | 6 | 3 | 0 | 0 | 2 | 0 | 4.74 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 74 | 60 | 0 | 6 | 4 | 3.87 | .305 | 1.29 | 6.9 | 4.7 | 9.2 | 79.0 | 61 | 34 | 34 | 7 | 41 | 81 | 0 | 6 | 5 | 0 | 0 | 2 | 11 | 3.73 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 71 | 62 | 0 | 5 | 2 | 4.72 | .331 | 1.46 | 6.6 | 6.6 | 8.1 | 68.2 | 50 | 36 | 36 | 7 | 50 | 61 | 0 | 6 | 0 | 0 | 0 | 2 | 1 | 4.84 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 76 | 53 | 0 | 6 | 4 | 3.99 | .312 | 1.35 | 9.6 | 2.6 | 6.8 | 65.1 | 69 | 31 | 29 | 11 | 19 | 49 | 0 | 2 | 2 | 0 | 0 | 1 | 0 | 4.62 |
| RP | Hoffman, T.Hoffman, Trevor >> | 31 | 1998 | R | 75 | 48 | 0 | 1 | 3 | 4.98 | .328 | 1.43 | 9.8 | 3.1 | 6.4 | 56.0 | 61 | 36 | 31 | 5 | 19 | 40 | 0 | 2 | 3 | 0 | 0 | 2 | 3 | 3.86 |