| SP | Scherzer, M.Scherzer, Max >> | 34 | 2018 | R | 88 | 33 | 33 | 8 | 12 | 5.29 | .334 | 1.48 | 9.8 | 3.5 | 8.9 | 187.0 | 203 | 113 | 110 | 27 | 73 | 185 | 0 | 0 | 0 | 0 | 14 | 5 | 5 | 4.15 |
| SP | Brown, M.Brown, Mordecai >> | 32 | 1908 | R | 85 | 34 | 33 | 6 | 19 | 5.52 | .329 | 1.45 | 10.1 | 3.1 | 4.8 | 197.1 | 220 | 127 | 121 | 26 | 67 | 106 | 6 | 0 | 0 | 1 | 12 | 3 | 4 | 4.71 |
| SP | Cicotte, E.Cicotte, Eddie >> | 33 | 1917 | R | 75 | 33 | 31 | 7 | 17 | 6.09 | .338 | 1.52 | 10.1 | 3.6 | 5.5 | 167.0 | 188 | 120 | 113 | 28 | 66 | 102 | 4 | 1 | 0 | 1 | 11 | 2 | 2 | 5.18 |
| RP | Wagner, B.Wagner, Billy >> | 28 | 1999 | L | 95 | 91 | 0 | 3 | 2 | 3.89 | .287 | 1.20 | 7.1 | 3.7 | 9.3 | 90.1 | 71 | 39 | 39 | 13 | 37 | 93 | 0 | 2 | 1 | 0 | 0 | 1 | 3 | 4.08 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 85 | 108 | 0 | 5 | 4 | 3.60 | .248 | 0.99 | 7.3 | 1.6 | 7.5 | 95.0 | 77 | 40 | 38 | 12 | 17 | 79 | 0 | 5 | 1 | 0 | 0 | 0 | 0 | 3.52 |
| RP | Gallegos, G.Gallegos, Giovanny >> | 27 | 2019 | R | 82 | 76 | 0 | 4 | 2 | 3.12 | .262 | 1.07 | 7.3 | 2.3 | 8.0 | 75.0 | 61 | 28 | 26 | 9 | 19 | 67 | 0 | 5 | 1 | 0 | 0 | 0 | 6 | 3.53 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 76 | 50 | 0 | 5 | 2 | 4.24 | .292 | 1.24 | 8.5 | 2.6 | 7.1 | 51.0 | 48 | 26 | 24 | 6 | 15 | 40 | 0 | 3 | 2 | 0 | 0 | 0 | 0 | 3.84 |
| RP | Williams, D.Williams, Devin >> | 28 | 2023 | R | 73 | 30 | 0 | 2 | 1 | 3.18 | .341 | 1.48 | 7.4 | 6.1 | 5.8 | 28.1 | 23 | 11 | 10 | 1 | 19 | 18 | 0 | 1 | 0 | 0 | 0 | 2 | 1 | 4.43 |
| SP | Krause, H.Krause, Harry >> | 21 | 1909 | L | 72 | 23 | 1 | 1 | 2 | 3.46 | .303 | 1.28 | 7.8 | 3.8 | 4.8 | 93.2 | 81 | 38 | 36 | 8 | 39 | 50 | 0 | 0 | 0 | 0 | 0 | 2 | 2 | 4.37 |