| SP | Johnson, W.Johnson, Walter >> | 26 | 1913 | R | 95 | 28 | 28 | 6 | 10 | 4.22 | .305 | 1.28 | 9.6 | 2.0 | 5.1 | 170.2 | 181 | 88 | 80 | 15 | 38 | 96 | 0 | 0 | 0 | 0 | 11 | 6 | 2 | 3.79 |
| SP | Nelson, R.Nelson, Roger >> | 28 | 1972 | R | 85 | 27 | 27 | 3 | 9 | 5.60 | .353 | 1.61 | 11.5 | 3.0 | 5.4 | 135.0 | 172 | 91 | 84 | 13 | 45 | 81 | 0 | 0 | 0 | 0 | 7 | 4 | 5 | 4.14 |
| SP | Waddell, R.Waddell, Rube >> | 29 | 1905 | L | 67 | 25 | 25 | 11 | 8 | 4.85 | .328 | 1.44 | 9.0 | 4.0 | 5.2 | 167.0 | 167 | 113 | 90 | 22 | 74 | 96 | 2 | 0 | 0 | 1 | 14 | 3 | 9 | 4.95 |
| RP | Treinen, B.Treinen, Blake >> | 30 | 2018 | R | 79 | 69 | 0 | 5 | 3 | 4.04 | .351 | 1.61 | 8.9 | 5.6 | 9.7 | 69.0 | 68 | 36 | 31 | 6 | 43 | 74 | 0 | 3 | 2 | 0 | 0 | 1 | 7 | 3.90 |
| SU | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 93 | 56 | 0 | 2 | 6 | 4.64 | .315 | 1.36 | 7.7 | 4.7 | 9.5 | 54.1 | 46 | 29 | 28 | 7 | 28 | 57 | 0 | 4 | 5 | 0 | 0 | 1 | 0 | 4.19 |
| CL | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 99 | 47 | 0 | 5 | 8 | 5.77 | .358 | 1.63 | 9.9 | 4.9 | 10.9 | 48.1 | 53 | 34 | 31 | 10 | 26 | 58 | 0 | 15 | 6 | 0 | 0 | 2 | 0 | 5.04 |
| RP | Hochevar, L.Hochevar, Luke >> | 30 | 2013 | R | 78 | 56 | 0 | 2 | 1 | 3.64 | .285 | 1.18 | 7.3 | 3.4 | 9.2 | 59.1 | 48 | 24 | 24 | 6 | 22 | 60 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 3.46 |