| SP | deGrom, J.deGrom, Jacob >> | 33 | 2021 | R | 100 | 38 | 38 | 14 | 8 | 3.75 | .281 | 1.15 | 8.4 | 2.0 | 9.3 | 225.2 | 210 | 97 | 94 | 26 | 50 | 232 | 0 | 0 | 0 | 0 | 24 | 5 | 0 | 3.17 |
| SP | Fernandez, J.Fernandez, Jose >> | 21 | 2013 | R | 76 | 35 | 35 | 18 | 7 | 3.64 | .307 | 1.30 | 7.6 | 4.1 | 7.2 | 220.0 | 186 | 90 | 89 | 23 | 99 | 175 | 0 | 0 | 0 | 0 | 23 | 7 | 2 | 4.21 |
| SP | Kluber, C.Kluber, Corey # >> | 31 | 2017 | R | 90 | 34 | 34 | 15 | 11 | 4.03 | .270 | 1.09 | 7.9 | 2.0 | 8.5 | 216.2 | 189 | 101 | 97 | 31 | 48 | 204 | 6 | 0 | 0 | 3 | 18 | 3 | 2 | 3.69 |
| SP | Fernandez, S.Fernandez, Sid † >> | 23 | 1985 | L | 49 | 33 | 33 | 12 | 7 | 2.78 | .275 | 1.11 | 6.4 | 3.6 | 8.9 | 226.1 | 161 | 71 | 70 | 17 | 91 | 224 | 1 | 0 | 0 | 0 | 24 | 6 | 5 | 3.28 |
| RP | Miller, A.Miller, Andrew >> | 29 | 2014 | L | 88 | 94 | 0 | 4 | 4 | 3.84 | .264 | 1.06 | 6.8 | 2.8 | 10.1 | 119.2 | 90 | 52 | 51 | 11 | 37 | 134 | 0 | 2 | 4 | 0 | 0 | 2 | 5 | 2.93 |
| RP | Capps, C.Capps, Carter >> | 24 | 2015 | R | 86 | 71 | 0 | 4 | 6 | 3.75 | .298 | 1.26 | 7.3 | 4.1 | 10.0 | 86.1 | 70 | 37 | 36 | 6 | 39 | 96 | 0 | 2 | 5 | 0 | 0 | 1 | 7 | 3.07 |
| RP | Devine, J.Devine, Joey >> | 25 | 2008 | R | 81 | 60 | 0 | 7 | 2 | 4.02 | .316 | 1.34 | 8.4 | 3.8 | 7.0 | 62.2 | 58 | 31 | 28 | 7 | 26 | 48 | 0 | 0 | 1 | 0 | 0 | 3 | 0 | 4.32 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 71 | 42 | 0 | 1 | 2 | 2.45 | .263 | 1.07 | 4.8 | 5.0 | 8.4 | 47.2 | 25 | 14 | 13 | 3 | 26 | 44 | 0 | 3 | 1 | 0 | 0 | 0 | 0 | 3.62 |
| CL | Gagne, E.Gagne, Eric # >> | 27 | 2003 | R | 98 | 76 | 0 | 4 | 11 | 5.91 | .358 | 1.66 | 9.1 | 5.8 | 9.9 | 70.0 | 71 | 49 | 46 | 8 | 45 | 77 | 0 | 38 | 10 | 0 | 0 | 1 | 1 | 4.26 |
| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 84 | 34 | 32 | 14 | 14 | 4.56 | .306 | 1.26 | 8.2 | 3.2 | 8.6 | 211.1 | 192 | 116 | 107 | 24 | 75 | 202 | 3 | 0 | 1 | 1 | 17 | 13 | 2 | 3.82 |