| SP | Arrieta, J.Arrieta, Jake >> | 29 | 2015 | R | 93 | 31 | 31 | 12 | 8 | 3.76 | .299 | 1.26 | 8.7 | 2.7 | 7.9 | 174.2 | 168 | 82 | 73 | 21 | 52 | 153 | 1 | 0 | 0 | 0 | 17 | 4 | 2 | 3.78 |
| SP | Leonard, D.Leonard, Dutch >> | 22 | 1914 | L | 91 | 31 | 31 | 11 | 12 | 4.44 | .312 | 1.35 | 9.0 | 3.2 | 5.3 | 186.2 | 185 | 99 | 92 | 19 | 67 | 109 | 1 | 0 | 0 | 0 | 19 | 2 | 2 | 4.27 |
| SP | Mathewson, C.Mathewson, Christy >> | 29 | 1909 | R | 86 | 30 | 30 | 14 | 4 | 3.33 | .265 | 1.07 | 7.4 | 2.3 | 3.6 | 192.0 | 158 | 79 | 71 | 20 | 48 | 77 | 1 | 0 | 0 | 1 | 19 | 2 | 4 | 4.33 |
| SP | Alexander, P.Alexander, Pete >> | 28 | 1915 | R | 88 | 30 | 30 | 12 | 12 | 3.69 | .270 | 1.11 | 7.7 | 2.3 | 3.8 | 214.2 | 184 | 93 | 88 | 21 | 54 | 90 | 10 | 0 | 0 | 2 | 16 | 0 | 1 | 4.19 |
| SP | Fernandez, J.Fernandez, Jose # >> | 21 | 2013 | R | 76 | 30 | 30 | 14 | 10 | 4.63 | .311 | 1.32 | 8.6 | 3.3 | 6.9 | 175.0 | 167 | 93 | 90 | 19 | 64 | 134 | 1 | 0 | 0 | 1 | 16 | 6 | 4 | 4.08 |
| RP | Chapman, A.Chapman, Aroldis † >> | 26 | 2014 | L | 93 | 78 | 0 | 7 | 3 | 3.09 | .298 | 1.26 | 5.0 | 6.4 | 10.5 | 99.0 | 55 | 36 | 34 | 6 | 70 | 115 | 0 | 6 | 3 | 0 | 0 | 1 | 4 | 3.62 |
| RP | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 84 | 56 | 0 | 3 | 6 | 2.49 | .287 | 1.18 | 7.8 | 2.9 | 8.9 | 68.2 | 59 | 19 | 19 | 4 | 22 | 67 | 0 | 9 | 1 | 0 | 0 | 2 | 0 | 2.85 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 78 | 34 | 0 | 2 | 3 | 2.68 | .271 | 1.07 | 5.4 | 4.3 | 7.2 | 40.1 | 24 | 12 | 12 | 3 | 19 | 32 | 0 | 4 | 0 | 0 | 0 | 2 | 4 | 3.95 |
| RP | Rodriguez, F.Rodriguez, Francisco >> | 22 | 2004 | R | 55 | 6 | 0 | 1 | 1 | 1.69 | .333 | 1.50 | 7.2 | 7.2 | 7.2 | 5.1 | 4 | 1 | 1 | 0 | 4 | 4 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 3.80 |
| RP | Eichhorn, M.Eichhorn, Mark >> | 26 | 1986 | R | 48 | 33 | 0 | 3 | 3 | 4.68 | .322 | 1.40 | 7.8 | 4.8 | 7.1 | 75.0 | 65 | 39 | 39 | 10 | 40 | 59 | 0 | 0 | 0 | 0 | 0 | 2 | 1 | 4.84 |