| SP | Martinez, P.Martinez, Pedro >> | 29 | 2000 | R | 100 | 13 | 13 | 7 | 3 | 2.54 | .235 | 0.92 | 6.7 | 1.6 | 8.3 | 95.2 | 71 | 30 | 27 | 7 | 17 | 88 | 7 | 0 | 0 | 3 | 9 | 0 | 2 | 2.64 |
| SP | Fernandez, S.Fernandez, Sid >> | 23 | 1985 | L | 49 | 12 | 12 | 2 | 6 | 4.79 | .331 | 1.47 | 7.5 | 5.7 | 8.9 | 62.0 | 52 | 36 | 33 | 8 | 39 | 61 | 0 | 0 | 0 | 0 | 5 | 1 | 1 | 4.65 |
| SP | Kluber, C.Kluber, Corey >> | 31 | 2017 | R | 90 | 12 | 12 | 6 | 4 | 3.41 | .289 | 1.21 | 7.7 | 3.2 | 7.3 | 87.0 | 74 | 33 | 33 | 11 | 31 | 71 | 1 | 0 | 0 | 0 | 9 | 1 | 3 | 4.11 |
| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 83 | 12 | 12 | 5 | 4 | 4.05 | .270 | 1.07 | 7.5 | 2.2 | 9.3 | 86.2 | 72 | 43 | 39 | 15 | 21 | 89 | 2 | 0 | 0 | 0 | 7 | 3 | 2 | 4.03 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 30 | 0 | 2 | 2 | 2.59 | .266 | 1.05 | 6.1 | 3.5 | 7.0 | 31.1 | 21 | 9 | 9 | 5 | 12 | 24 | 0 | 0 | 4 | 0 | 0 | 1 | 0 | 4.81 |
| RP | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 85 | 22 | 0 | 2 | 1 | 2.29 | .192 | 0.71 | 4.3 | 2.4 | 7.6 | 19.2 | 9 | 5 | 5 | 4 | 5 | 16 | 0 | 2 | 1 | 0 | 0 | 0 | 0 | 4.84 |
| RP | Treinen, B.Treinen, Blake >> | 30 | 2018 | R | 80 | 12 | 0 | 2 | 0 | 3.27 | .327 | 1.45 | 9.0 | 4.1 | 7.4 | 11.0 | 11 | 4 | 4 | 2 | 5 | 9 | 0 | 0 | 1 | 0 | 0 | 0 | 2 | 5.09 |