| SP | Martinez, P.Martinez, Pedro † >> | 29 | 2000 | R | 100 | 31 | 31 | 18 | 7 | 2.95 | .265 | 1.07 | 7.4 | 2.2 | 7.0 | 231.2 | 190 | 77 | 76 | 17 | 57 | 180 | 12 | 0 | 0 | 3 | 21 | 3 | 2 | 3.18 |
| SP | Fernandez, S.Fernandez, Sid >> | 23 | 1985 | L | 49 | 30 | 30 | 19 | 3 | 2.95 | .260 | 1.04 | 5.4 | 4.0 | 7.2 | 207.2 | 125 | 70 | 68 | 20 | 92 | 165 | 3 | 0 | 0 | 0 | 20 | 2 | 2 | 4.02 |
| SP | Cole, G.Cole, Gerrit † >> | 28 | 2019 | R | 91 | 29 | 29 | 11 | 10 | 3.72 | .308 | 1.31 | 8.5 | 3.3 | 8.8 | 179.0 | 170 | 81 | 74 | 26 | 65 | 176 | 1 | 0 | 0 | 0 | 16 | 4 | 8 | 4.08 |
| SP | Blue, V.Blue, Vida † # >> | 22 | 1971 | L | 80 | 29 | 29 | 18 | 6 | 2.98 | .259 | 1.03 | 6.3 | 2.9 | 6.3 | 220.1 | 155 | 79 | 73 | 20 | 71 | 153 | 15 | 0 | 0 | 4 | 19 | 5 | 4 | 3.83 |
| RP | Doolittle, S.Doolittle, Sean >> | 31 | 2018 | L | 99 | 75 | 0 | 6 | 3 | 2.61 | .250 | 0.99 | 5.7 | 3.2 | 9.4 | 76.0 | 48 | 23 | 22 | 8 | 27 | 79 | 0 | 6 | 1 | 0 | 0 | 1 | 4 | 3.39 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 72 | 0 | 3 | 3 | 3.66 | .262 | 1.06 | 5.9 | 3.7 | 10.0 | 64.0 | 42 | 26 | 26 | 7 | 26 | 71 | 0 | 7 | 2 | 0 | 0 | 0 | 0 | 3.42 |
| RP | Capps, C.Capps, Carter >> | 24 | 2015 | R | 84 | 53 | 0 | 4 | 2 | 2.96 | .251 | 1.01 | 7.2 | 2.0 | 10.8 | 45.2 | 36 | 15 | 15 | 5 | 10 | 54 | 0 | 4 | 5 | 0 | 0 | 0 | 2 | 2.71 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 75 | 29 | 0 | 3 | 1 | 1.50 | .234 | 0.92 | 4.8 | 3.5 | 9.0 | 36.0 | 19 | 6 | 6 | 3 | 14 | 36 | 0 | 4 | 0 | 0 | 0 | 0 | 1 | 3.25 |
| RP | Rhodes, A.Rhodes, Arthur >> | 32 | 2001 | L | 64 | 35 | 0 | 2 | 2 | 1.93 | .240 | 0.95 | 6.8 | 2.0 | 10.7 | 32.2 | 24 | 8 | 7 | 2 | 7 | 38 | 0 | 3 | 1 | 0 | 0 | 0 | 1 | 2.09 |