| SP | Waddell, R.Waddell, Rube >> | 29 | 1905 | L | 67 | 12 | 12 | 4 | 5 | 5.13 | .333 | 1.49 | 9.4 | 4.1 | 7.0 | 66.2 | 69 | 38 | 38 | 6 | 30 | 51 | 2 | 0 | 0 | 0 | 6 | 1 | 1 | 4.05 |
| RP | Street, H.Street, Huston >> | 29 | 2012 | R | 96 | 28 | 0 | 1 | 1 | 2.80 | .316 | 1.36 | 6.4 | 5.9 | 9.0 | 35.1 | 25 | 11 | 11 | 1 | 23 | 35 | 0 | 2 | 1 | 0 | 0 | 1 | 1 | 3.43 |
| RP | Gregerson, L.Gregerson, Luke >> | 26 | 2010 | R | 73 | 29 | 0 | 1 | 1 | 5.00 | .325 | 1.44 | 10.0 | 3.0 | 6.5 | 36.0 | 40 | 27 | 20 | 6 | 12 | 26 | 0 | 3 | 3 | 0 | 0 | 0 | 0 | 4.72 |
| RP | Messersmith, A.Messersmith, Andy >> | 23 | 1968 | R | 58 | 22 | 0 | 3 | 2 | 4.17 | .276 | 1.15 | 7.2 | 3.1 | 4.2 | 41.0 | 33 | 19 | 19 | 6 | 14 | 19 | 0 | 2 | 1 | 0 | 0 | 0 | 0 | 5.00 |
| SP | Saberhagen, B.Saberhagen, Bret >> | 25 | 1989 | R | 51 | 3 | 0 | 1 | 0 | 0.00 | .200 | 0.75 | 6.8 | 0.0 | 4.5 | 4.0 | 3 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 2.00 |
| SP | Liriano, F.Liriano, Francisco >> | 23 | 2006 | L | 58 | 12 | 0 | 3 | 1 | 5.52 | .307 | 1.33 | 8.1 | 4.0 | 8.1 | 29.1 | 26 | 18 | 18 | 6 | 13 | 26 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 5.24 |