| SP | Greinke, Z.Greinke, Zack † >> | 32 | 2015 | R | 94 | 32 | 32 | 12 | 14 | 4.51 | .311 | 1.34 | 9.4 | 2.7 | 5.2 | 211.2 | 220 | 108 | 106 | 18 | 64 | 123 | 7 | 0 | 0 | 1 | 15 | 3 | 10 | 3.90 |
| SP | Santana, J.Santana, Johan >> | 25 | 2004 | L | 85 | 32 | 32 | 9 | 12 | 4.82 | .312 | 1.35 | 8.6 | 3.6 | 7.7 | 201.2 | 192 | 108 | 108 | 25 | 80 | 172 | 0 | 0 | 0 | 0 | 16 | 2 | 7 | 4.13 |
| SP | Horlen, J.Horlen, Joe # >> | 27 | 1964 | R | 78 | 31 | 31 | 14 | 13 | 5.19 | .327 | 1.44 | 9.8 | 3.2 | 4.6 | 192.2 | 209 | 111 | 111 | 25 | 69 | 99 | 2 | 0 | 0 | 1 | 12 | 3 | 5 | 4.79 |
| SP | Marichal, J.Marichal, Juan >> | 29 | 1966 | R | 76 | 31 | 31 | 9 | 16 | 4.86 | .303 | 1.30 | 8.8 | 2.9 | 5.0 | 215.0 | 210 | 128 | 116 | 37 | 69 | 119 | 7 | 0 | 0 | 0 | 13 | 2 | 6 | 5.12 |
| SP | Clemens, R.Clemens, Roger >> | 24 | 1986 | R | 69 | 30 | 30 | 7 | 14 | 4.09 | .305 | 1.29 | 8.0 | 3.7 | 5.6 | 207.0 | 183 | 100 | 94 | 27 | 84 | 129 | 5 | 0 | 0 | 1 | 17 | 6 | 5 | 4.75 |
| SU | Saito, T.Saito, Takashi >> | 37 | 2007 | R | 91 | 56 | 0 | 0 | 4 | 6.29 | .356 | 1.58 | 9.7 | 4.7 | 8.7 | 54.1 | 58 | 40 | 38 | 11 | 28 | 52 | 0 | 4 | 9 | 0 | 0 | 4 | 0 | 5.50 |
| RP | Benitez, A.Benitez, Armando >> | 32 | 2004 | R | 81 | 74 | 0 | 8 | 1 | 3.64 | .290 | 1.19 | 6.8 | 3.9 | 6.4 | 89.0 | 67 | 39 | 36 | 14 | 39 | 63 | 0 | 2 | 1 | 0 | 0 | 3 | 0 | 5.04 |
| RP | Clippard, T.Clippard, Tyler >> | 26 | 2011 | R | 79 | 56 | 0 | 3 | 3 | 5.18 | .303 | 1.27 | 7.5 | 4.0 | 8.2 | 66.0 | 55 | 40 | 38 | 9 | 29 | 60 | 0 | 3 | 3 | 0 | 0 | 2 | 1 | 4.36 |
| RP | Betancourt, R.Betancourt, Rafael >> | 32 | 2007 | R | 76 | 36 | 0 | 3 | 2 | 5.40 | .318 | 1.40 | 10.4 | 2.3 | 8.1 | 40.0 | 46 | 24 | 24 | 5 | 10 | 36 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 3.58 |
| RP | Marmol, C.Marmol, Carlos >> | 26 | 2008 | R | 70 | 31 | 0 | 0 | 0 | 2.00 | .275 | 1.11 | 6.5 | 3.5 | 9.3 | 36.0 | 26 | 10 | 8 | 5 | 14 | 37 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 4.00 |
| SP | Scherzer, M.Scherzer, Max >> | 33 | 2017 | R | 95 | 4 | 0 | 0 | 0 | 1.69 | .333 | 1.31 | 7.2 | 5.4 | 10.8 | 5.1 | 4 | 1 | 1 | 0 | 3 | 6 | 0 | 0 | 0 | 0 | 0 | 1 | 2 | 3.00 |