| SP | Kershaw, C.Kershaw, Clayton >> | 28 | 2016 | L | 99 | 30 | 30 | 9 | 13 | 3.96 | .289 | 1.21 | 8.5 | 2.3 | 8.2 | 215.2 | 204 | 101 | 95 | 24 | 56 | 196 | 6 | 0 | 0 | 3 | 16 | 3 | 8 | 3.45 |
| SP | Richard, J.Richard, J.R. >> | 30 | 1980 | R | 90 | 29 | 29 | 14 | 10 | 3.93 | .302 | 1.25 | 6.7 | 4.6 | 7.0 | 187.2 | 139 | 87 | 82 | 14 | 96 | 145 | 3 | 0 | 0 | 2 | 17 | 9 | 2 | 4.11 |
| SP | Johnson, R.Johnson, Randy # >> | 41 | 2004 | L | 83 | 29 | 29 | 15 | 8 | 3.93 | .287 | 1.17 | 8.3 | 2.3 | 7.6 | 206.0 | 189 | 93 | 90 | 22 | 52 | 173 | 6 | 0 | 0 | 1 | 17 | 8 | 3 | 3.58 |
| SP | Cueto, J.Cueto, Johnny >> | 28 | 2014 | R | 75 | 29 | 29 | 11 | 10 | 4.22 | .317 | 1.38 | 8.9 | 3.6 | 5.3 | 206.2 | 204 | 99 | 97 | 25 | 82 | 122 | 7 | 0 | 0 | 0 | 15 | 2 | 3 | 4.62 |
| RP | Doolittle, S.Doolittle, Sean † $ >> | 31 | 2018 | L | 99 | 74 | 0 | 10 | 6 | 2.27 | .250 | 0.97 | 6.2 | 2.5 | 7.5 | 99.0 | 68 | 25 | 25 | 7 | 28 | 83 | 0 | 17 | 4 | 0 | 0 | 3 | 4 | 3.18 |
| RP | Papelbon, J.Papelbon, Jonathan >> | 27 | 2007 | R | 92 | 54 | 0 | 3 | 3 | 2.18 | .282 | 1.13 | 6.5 | 3.6 | 10.5 | 62.0 | 45 | 15 | 15 | 3 | 25 | 72 | 0 | 11 | 3 | 0 | 0 | 3 | 0 | 2.66 |
| RP | Boxberger, B.Boxberger, Brad >> | 26 | 2014 | R | 83 | 29 | 0 | 5 | 1 | 2.51 | .246 | 0.87 | 5.5 | 2.6 | 8.0 | 28.2 | 17 | 8 | 8 | 4 | 8 | 25 | 0 | 4 | 0 | 0 | 0 | 3 | 1 | 4.25 |
| RP | Bautista, F.Bautista, Félix >> | 28 | 2023 | R | 75 | 13 | 0 | 1 | 0 | 1.26 | .218 | 0.84 | 4.5 | 3.2 | 9.0 | 14.1 | 7 | 2 | 2 | 1 | 5 | 14 | 0 | 4 | 0 | 0 | 0 | 0 | 1 | 3.00 |
| RP | Britton, Z.Britton, Zach >> | 28 | 2016 | L | 78 | 11 | 0 | 0 | 0 | 0.79 | .227 | 0.79 | 4.1 | 3.3 | 13.9 | 11.1 | 5 | 1 | 1 | 0 | 4 | 17 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1.27 |