| SP | Hunter, C.Hunter, Catfish † >> | 26 | 1972 | R | 88 | 29 | 29 | 16 | 6 | 3.40 | .276 | 1.13 | 7.5 | 2.7 | 5.5 | 209.1 | 174 | 91 | 79 | 21 | 62 | 127 | 14 | 0 | 0 | 2 | 17 | 3 | 6 | 4.02 |
| SP | Waddell, R.Waddell, Rube >> | 29 | 1905 | L | 81 | 28 | 28 | 10 | 9 | 4.14 | .305 | 1.30 | 8.4 | 3.3 | 5.1 | 185.0 | 173 | 89 | 85 | 18 | 67 | 105 | 3 | 0 | 0 | 1 | 14 | 3 | 5 | 4.26 |
| SP | Harden, R.Harden, Rich # >> | 24 | 2005 | R | 64 | 26 | 26 | 9 | 5 | 4.53 | .319 | 1.39 | 8.9 | 3.6 | 6.4 | 143.0 | 142 | 75 | 72 | 16 | 57 | 101 | 0 | 0 | 0 | 0 | 14 | 2 | 7 | 4.28 |
| RP | Devine, J.Devine, Joey >> | 25 | 2008 | R | 89 | 68 | 0 | 10 | 4 | 3.96 | .304 | 1.28 | 7.3 | 4.2 | 7.8 | 109.0 | 89 | 48 | 48 | 7 | 51 | 95 | 0 | 6 | 4 | 0 | 0 | 3 | 0 | 3.58 |
| RP | Abad, F.Abad, Fernando >> | 28 | 2014 | L | 79 | 50 | 0 | 5 | 4 | 3.64 | .282 | 1.15 | 7.9 | 2.6 | 6.1 | 81.2 | 71 | 34 | 33 | 11 | 23 | 55 | 0 | 3 | 3 | 0 | 0 | 2 | 0 | 4.33 |
| RP | Wendelken, J.Wendelken, J.B. >> | 26 | 2019 | R | 60 | 41 | 0 | 5 | 5 | 4.30 | .314 | 1.38 | 8.7 | 3.8 | 8.1 | 52.1 | 50 | 25 | 25 | 9 | 22 | 47 | 0 | 6 | 7 | 0 | 0 | 0 | 1 | 4.71 |
| RP | Madson, R.Madson, Ryan >> | 37 | 2017 | R | 84 | 48 | 0 | 2 | 5 | 3.27 | .279 | 1.16 | 8.9 | 1.6 | 6.0 | 71.2 | 70 | 27 | 26 | 5 | 13 | 47 | 0 | 5 | 1 | 0 | 0 | 0 | 0 | 3.14 |
| RP | Miller, M.Miller, Mason >> | 26 | 2025 | R | 68 | 31 | 0 | 4 | 3 | 2.68 | .277 | 1.09 | 6.1 | 3.6 | 8.4 | 47.0 | 32 | 14 | 14 | 3 | 19 | 44 | 0 | 1 | 1 | 0 | 0 | 3 | 1 | 3.36 |
| RP | Doolittle, S.Doolittle, Sean >> | 27 | 2014 | L | 92 | 25 | 0 | 1 | 2 | 2.25 | .309 | 1.31 | 8.2 | 3.7 | 5.1 | 32.0 | 29 | 9 | 8 | 2 | 13 | 18 | 0 | 1 | 2 | 0 | 0 | 1 | 0 | 4.00 |
| RP | Wuertz, M.Wuertz, Michael # >> | 31 | 2009 | R | 61 | 38 | 0 | 2 | 4 | 5.70 | .346 | 1.56 | 9.4 | 4.8 | 8.4 | 47.1 | 49 | 34 | 30 | 6 | 25 | 44 | 0 | 4 | 0 | 0 | 0 | 1 | 3 | 4.45 |