| SP | Verlander, J.Verlander, Justin >> | 28 | 2011 | R | 92 | 6 | 6 | 2 | 2 | 3.99 | .343 | 1.57 | 11.8 | 2.4 | 6.2 | 38.1 | 50 | 22 | 17 | 3 | 10 | 26 | 1 | 0 | 0 | 0 | 3 | 0 | 1 | 3.45 |
| SP | Skubal, T.Skubal, Tarik # >> | 28 | 2025 | L | 89 | 6 | 6 | 2 | 1 | 4.85 | .324 | 1.41 | 10.6 | 2.1 | 8.3 | 39.0 | 46 | 22 | 21 | 5 | 9 | 36 | 0 | 0 | 0 | 0 | 4 | 1 | 1 | 3.59 |
| SP | Scherzer, M.Scherzer, Max >> | 29 | 2013 | R | 81 | 6 | 6 | 2 | 2 | 7.31 | .366 | 1.66 | 10.9 | 4.2 | 8.0 | 28.1 | 34 | 24 | 23 | 5 | 13 | 25 | 1 | 0 | 0 | 0 | 2 | 2 | 1 | 5.14 |
| SP | Flaherty, J.Flaherty, Jack >> | 28 | 2024 | R | 75 | 5 | 5 | 2 | 1 | 4.97 | .303 | 1.30 | 9.7 | 2.2 | 9.0 | 25.1 | 27 | 14 | 14 | 2 | 6 | 25 | 0 | 0 | 0 | 0 | 3 | 0 | 0 | 2.76 |
| SP | Robinson, J.Robinson, Jeff >> | 27 | 1988 | R | 65 | 6 | 4 | 1 | 4 | 5.27 | .339 | 1.54 | 9.0 | 5.0 | 7.3 | 27.1 | 27 | 16 | 16 | 3 | 15 | 22 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 4.48 |
| RP | Holton, T.Holton, Tyler >> | 28 | 2024 | L | 80 | 16 | 0 | 1 | 1 | 2.73 | .288 | 1.22 | 7.6 | 3.5 | 4.8 | 26.1 | 22 | 9 | 8 | 2 | 10 | 14 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 4.08 |
| RP | Greene, S.Greene, Shane >> | 30 | 2019 | R | 83 | 17 | 0 | 2 | 2 | 3.72 | .333 | 1.50 | 9.0 | 4.7 | 7.1 | 19.1 | 19 | 9 | 8 | 4 | 10 | 15 | 0 | 2 | 0 | 0 | 0 | 0 | 0 | 5.74 |
| RP | Wilson, J.Wilson, Justin >> | 29 | 2017 | L | 73 | 12 | 0 | 0 | 0 | 0.00 | .306 | 1.24 | 6.5 | 4.9 | 12.3 | 11.1 | 8 | 2 | 0 | 0 | 6 | 15 | 0 | 2 | 0 | 0 | 0 | 1 | 2 | 2.18 |
| RP | Rondon, B.Rondon, Bruce >> | 25 | 2016 | R | 59 | 7 | 0 | 0 | 0 | 0.84 | .220 | 0.84 | 6.3 | 1.8 | 8.1 | 10.2 | 7 | 1 | 1 | 1 | 2 | 9 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 3.10 |
| RP | Walker, J.Walker, Jamie >> | 31 | 2002 | L | 47 | 8 | 0 | 0 | 0 | 0.00 | .143 | 0.50 | 3.0 | 1.5 | 6.8 | 12.0 | 4 | 0 | 0 | 0 | 2 | 9 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 2.00 |
| RP | Alburquerque, A.Alburquerque, Al >> | 25 | 2011 | R | 57 | 7 | 0 | 1 | 1 | 4.50 | .351 | 1.63 | 7.9 | 6.8 | 5.6 | 8.0 | 7 | 7 | 4 | 2 | 6 | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 7.25 |