| SP | Jimenez, U.Jimenez, Ubaldo # >> | 26 | 2010 | R | 40 | 22 | 22 | 10 | 9 | 4.36 | .301 | 1.29 | 8.5 | 3.2 | 7.3 | 150.2 | 141 | 73 | 73 | 15 | 53 | 121 | 4 | 0 | 0 | 2 | 10 | 1 | 9 | 3.77 |
| SP | De La Rosa, J.De La Rosa, Jorge >> | 30 | 2011 | L | 35 | 23 | 23 | 0 | 7 | 8.40 | .408 | 2.03 | 13.3 | 5.0 | 4.3 | 50.1 | 74 | 51 | 47 | 15 | 28 | 24 | 0 | 0 | 0 | 0 | 0 | 2 | 1 | 7.74 |
| SP | Chacin, J.Chacin, Jhoulys >> | 22 | 2010 | R | 29 | 21 | 21 | 5 | 5 | 5.49 | .366 | 1.72 | 10.2 | 5.3 | 8.8 | 101.2 | 115 | 65 | 62 | 11 | 60 | 99 | 0 | 0 | 0 | 0 | 3 | 1 | 3 | 4.27 |
| SP | Thomson, J.Thomson, John >> | 28 | 2001 | R | 31 | 21 | 21 | 0 | 7 | 4.89 | .319 | 1.39 | 10.2 | 2.4 | 4.9 | 53.1 | 60 | 34 | 29 | 7 | 14 | 29 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 4.47 |
| SP | Gomber, A.Gomber, Austin >> | 27 | 2021 | L | 32 | 21 | 20 | 6 | 3 | 5.04 | .324 | 1.43 | 9.9 | 3.1 | 7.4 | 103.2 | 113 | 59 | 58 | 18 | 35 | 85 | 0 | 0 | 0 | 0 | 4 | 1 | 3 | 4.67 |
| RP | Ottavino, A.Ottavino, Adam >> | 32 | 2018 | R | 62 | 54 | 0 | 5 | 2 | 3.14 | .280 | 1.15 | 5.7 | 4.7 | 8.8 | 77.1 | 49 | 30 | 27 | 5 | 40 | 75 | 0 | 2 | 1 | 0 | 0 | 1 | 6 | 3.49 |
| RP | Miller, J.Miller, Justin >> | 28 | 2015 | R | 57 | 51 | 0 | 7 | 4 | 2.66 | .273 | 1.11 | 6.0 | 4.1 | 10.1 | 71.0 | 47 | 21 | 21 | 3 | 32 | 80 | 0 | 7 | 3 | 0 | 0 | 1 | 8 | 2.69 |
| RP | Betancourt, R.Betancourt, Rafael >> | 36 | 2011 | R | 64 | 42 | 0 | 2 | 0 | 2.76 | .245 | 0.95 | 7.3 | 1.4 | 9.2 | 58.2 | 47 | 18 | 18 | 1 | 9 | 59 | 0 | 2 | 2 | 0 | 0 | 1 | 1 | 1.71 |
| RP | Street, H.Street, Huston >> | 26 | 2009 | R | 53 | 27 | 0 | 0 | 6 | 5.74 | .322 | 1.39 | 8.7 | 4.2 | 5.5 | 26.2 | 25 | 17 | 17 | 7 | 12 | 16 | 0 | 0 | 2 | 0 | 0 | 1 | 0 | 6.77 |
| RP | Herges, M.Herges, Matt >> | 37 | 2007 | R | 38 | 24 | 0 | 0 | 2 | 5.13 | .255 | 1.03 | 6.6 | 2.8 | 6.2 | 26.1 | 19 | 15 | 15 | 4 | 8 | 18 | 0 | 3 | 2 | 0 | 0 | 0 | 0 | 4.54 |
| RP | Witasick, J.Witasick, Jay >> | 33 | 2005 | R | 35 | 21 | 0 | 0 | 0 | 4.23 | .297 | 1.27 | 8.0 | 3.7 | 9.0 | 27.2 | 24 | 14 | 13 | 3 | 11 | 27 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 3.67 |