| SP | Perez, P.Perez, Pascual # >> | 31 | 1988 | R | 82 | 21 | 21 | 7 | 11 | 5.05 | .321 | 1.41 | 9.0 | 3.7 | 6.3 | 133.2 | 133 | 78 | 75 | 23 | 55 | 93 | 2 | 0 | 0 | 0 | 9 | 2 | 2 | 5.14 |
| SP | Martinez, P.Martinez, Pedro † >> | 26 | 1997 | R | 92 | 23 | 23 | 10 | 8 | 3.80 | .298 | 1.25 | 7.3 | 4.0 | 9.2 | 158.2 | 128 | 73 | 67 | 12 | 70 | 162 | 6 | 0 | 0 | 2 | 13 | 4 | 2 | 3.34 |
| SP | Scherzer, M.Scherzer, Max # >> | 33 | 2017 | R | 99 | 22 | 22 | 10 | 4 | 3.30 | .276 | 1.13 | 7.2 | 3.0 | 9.0 | 155.1 | 124 | 63 | 57 | 17 | 51 | 155 | 0 | 0 | 0 | 0 | 15 | 3 | 0 | 3.47 |
| SP | Rogers, S.Rogers, Steve >> | 24 | 1973 | R | 69 | 20 | 20 | 9 | 7 | 4.15 | .346 | 1.55 | 8.7 | 5.3 | 5.0 | 141.0 | 136 | 72 | 65 | 12 | 83 | 78 | 4 | 0 | 0 | 0 | 11 | 5 | 4 | 4.87 |
| SP | Strasburg, S.Strasburg, Stephen >> | 28 | 2017 | R | 79 | 19 | 19 | 6 | 3 | 3.90 | .309 | 1.31 | 8.1 | 3.7 | 9.6 | 97.0 | 87 | 42 | 42 | 8 | 40 | 103 | 0 | 0 | 0 | 0 | 5 | 3 | 2 | 3.28 |
| RP | Clippard, T.Clippard, Tyler >> | 28 | 2013 | R | 80 | 52 | 0 | 2 | 3 | 2.76 | .277 | 1.10 | 6.2 | 3.7 | 8.6 | 65.1 | 45 | 20 | 20 | 6 | 27 | 62 | 0 | 1 | 3 | 0 | 0 | 3 | 0 | 3.68 |
| CL | Reardon, J.Reardon, Jeff † >> | 26 | 1981 | R | 86 | 49 | 0 | 3 | 7 | 2.68 | .269 | 1.04 | 6.2 | 3.2 | 5.2 | 57.0 | 39 | 18 | 17 | 6 | 20 | 33 | 0 | 29 | 5 | 0 | 0 | 4 | 0 | 4.47 |
| RP | Peralta, J.Peralta, Joel >> | 34 | 2010 | R | 83 | 47 | 0 | 5 | 2 | 4.59 | .282 | 1.18 | 8.3 | 2.3 | 7.8 | 51.0 | 47 | 28 | 26 | 12 | 13 | 44 | 0 | 1 | 2 | 0 | 0 | 0 | 0 | 5.10 |
| RP | Harvey, H.Harvey, Hunter >> | 28 | 2023 | R | 52 | 25 | 0 | 1 | 1 | 3.42 | .342 | 1.52 | 12.5 | 1.4 | 9.7 | 26.1 | 36 | 15 | 10 | 2 | 4 | 28 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 2.42 |
| SU | Kelley, S.Kelley, Shawn >> | 32 | 2016 | R | 63 | 46 | 0 | 4 | 2 | 3.58 | .284 | 1.13 | 9.2 | 1.1 | 8.3 | 50.1 | 51 | 21 | 20 | 5 | 6 | 46 | 0 | 6 | 5 | 0 | 0 | 3 | 1 | 3.00 |
| RP | Cordero, C.Cordero, Chad >> | 23 | 2005 | R | 50 | 25 | 0 | 0 | 0 | 1.91 | .261 | 1.02 | 6.4 | 2.9 | 6.8 | 28.1 | 20 | 6 | 6 | 2 | 9 | 21 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 3.50 |