| SP | Scherzer, M.Scherzer, Max >> | 33 | 2017 | R | 97 | 14 | 14 | 3 | 6 | 2.90 | .300 | 1.24 | 7.4 | 3.8 | 10.1 | 99.1 | 81 | 32 | 32 | 7 | 42 | 111 | 1 | 0 | 0 | 0 | 10 | 5 | 2 | 3.10 |
| SP | Johnson, R.Johnson, Randy >> | 41 | 2004 | L | 90 | 14 | 14 | 6 | 3 | 3.73 | .283 | 1.18 | 8.4 | 2.3 | 8.8 | 103.2 | 96 | 43 | 43 | 14 | 26 | 101 | 1 | 0 | 0 | 0 | 6 | 1 | 2 | 3.59 |
| SP | McClanahan, S.McClanahan, Shane >> | 25 | 2022 | L | 89 | 14 | 14 | 4 | 8 | 5.31 | .336 | 1.51 | 8.9 | 4.8 | 9.2 | 79.2 | 78 | 48 | 47 | 13 | 42 | 81 | 0 | 0 | 0 | 0 | 5 | 1 | 3 | 4.72 |
| SP | Schmidt, J.Schmidt, Jason >> | 30 | 2003 | R | 78 | 13 | 13 | 6 | 4 | 3.46 | .283 | 1.19 | 7.7 | 3.0 | 8.9 | 91.0 | 78 | 35 | 35 | 10 | 30 | 90 | 3 | 0 | 0 | 0 | 8 | 0 | 3 | 3.44 |
| RP | Saito, T.Saito, Takashi >> | 37 | 2007 | R | 90 | 37 | 0 | 4 | 4 | 2.36 | .227 | 0.84 | 5.3 | 2.4 | 9.3 | 53.1 | 31 | 15 | 14 | 7 | 14 | 55 | 0 | 5 | 3 | 0 | 0 | 2 | 0 | 3.55 |
| RP | Soriano, R.Soriano, Rafael >> | 24 | 2003 | R | 83 | 25 | 0 | 1 | 1 | 5.28 | .292 | 1.21 | 8.4 | 2.7 | 9.0 | 30.2 | 28 | 18 | 18 | 8 | 9 | 30 | 0 | 2 | 2 | 0 | 0 | 1 | 0 | 5.47 |
| RP | Rodney, F.Rodney, Fernando >> | 35 | 2012 | R | 80 | 13 | 0 | 0 | 1 | 1.08 | .242 | 0.96 | 7.3 | 1.7 | 10.1 | 16.2 | 13 | 2 | 2 | 0 | 3 | 18 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1.31 |
| RP | Valverde, J.Valverde, Jose >> | 24 | 2003 | R | 63 | 7 | 0 | 1 | 0 | 0.84 | .304 | 1.31 | 5.4 | 7.2 | 9.9 | 10.2 | 6 | 1 | 1 | 0 | 8 | 11 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 3.20 |
| RP | Pressly, R.Pressly, Ryan >> | 30 | 2019 | R | 54 | 7 | 0 | 0 | 0 | 2.08 | .278 | 1.15 | 9.0 | 2.3 | 10.1 | 8.2 | 8 | 2 | 2 | 1 | 2 | 9 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 3.13 |
| SP | Beckett, J.Beckett, Josh >> | 31 | 2011 | R | 55 | 3 | 0 | 1 | 1 | 13.50 | .500 | 3.00 | 27.0 | 9.0 | 22.5 | 2.2 | 6 | 4 | 4 | 0 | 2 | 5 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1.00 |