| SP | Greinke, Z.Greinke, Zack >> | 32 | 2015 | R | 94 | 12 | 12 | 5 | 5 | 3.51 | .286 | 1.18 | 8.8 | 1.9 | 6.3 | 89.2 | 87 | 39 | 35 | 9 | 19 | 62 | 2 | 0 | 0 | 1 | 6 | 2 | 3 | 3.63 |
| SP | Nelson, R.Nelson, Roger # >> | 28 | 1972 | R | 88 | 12 | 12 | 2 | 5 | 5.83 | .331 | 1.47 | 9.8 | 3.6 | 6.8 | 58.2 | 63 | 38 | 38 | 13 | 23 | 44 | 0 | 0 | 0 | 0 | 2 | 1 | 0 | 5.64 |
| SP | Hendricks, K.Hendricks, Kyle $ >> | 26 | 2016 | R | 72 | 13 | 12 | 5 | 5 | 5.18 | .336 | 1.52 | 9.4 | 4.3 | 7.9 | 73.0 | 76 | 44 | 42 | 9 | 35 | 64 | 1 | 0 | 0 | 1 | 3 | 0 | 1 | 4.29 |
| SP | Saberhagen, B.Saberhagen, Bret >> | 25 | 1989 | R | 66 | 13 | 12 | 7 | 2 | 4.76 | .339 | 1.51 | 10.6 | 3.1 | 5.5 | 79.1 | 93 | 43 | 42 | 12 | 27 | 48 | 2 | 0 | 0 | 0 | 6 | 2 | 3 | 4.86 |
| SP | Schilling, C.Schilling, Curt # >> | 36 | 2002 | R | 65 | 12 | 11 | 5 | 3 | 4.91 | .313 | 1.34 | 9.5 | 2.7 | 9.2 | 80.2 | 84 | 46 | 44 | 13 | 24 | 82 | 2 | 0 | 0 | 0 | 4 | 2 | 0 | 4.04 |
| RP | Miller, A.Miller, Andrew >> | 29 | 2014 | L | 87 | 37 | 0 | 2 | 0 | 4.50 | .312 | 1.28 | 7.8 | 3.8 | 11.3 | 36.0 | 31 | 22 | 18 | 4 | 15 | 45 | 0 | 2 | 1 | 0 | 0 | 3 | 1 | 3.44 |
| RP | Rivera, M.Rivera, Mariano >> | 39 | 2008 | R | 84 | 35 | 0 | 5 | 0 | 0.90 | .245 | 0.98 | 6.5 | 2.3 | 10.1 | 40.0 | 29 | 4 | 4 | 1 | 10 | 45 | 0 | 4 | 0 | 0 | 0 | 0 | 2 | 1.83 |
| RP | Hochevar, L.Hochevar, Luke >> | 30 | 2013 | R | 74 | 21 | 0 | 1 | 0 | 4.03 | .295 | 1.21 | 8.6 | 2.5 | 10.2 | 22.1 | 21 | 10 | 10 | 4 | 6 | 25 | 0 | 2 | 1 | 0 | 0 | 1 | 0 | 4.05 |
| RP | Williams, D.Williams, Devin >> | 28 | 2023 | R | 70 | 20 | 0 | 1 | 1 | 3.63 | .337 | 1.48 | 7.4 | 6.1 | 11.5 | 22.1 | 18 | 9 | 9 | 3 | 15 | 28 | 0 | 0 | 2 | 0 | 0 | 1 | 1 | 4.41 |